Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a member of the cancer/testis antigens (CTAs) protein family, which is family of proteins that are mainly expressed in tumors and testicular tissue, but they display low to no expression in other normal tissues.
It has been previously demonstrated that necrosis is associated with metastatic dissemination of cancer cells; however, how necrosis promotes tumor dissemination is not understood. In a recent study, researchers from Fred Hutchinson Cancer Center and University of Washington aimed to investigate the correlation between tumor dissemination and the formation of large contiguous zones of necrosis within the tumor core.
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, which lacks effective targeted therapies. Poly (ADP-ribose) polymerase (PARP) inhibitors such as olaparib are the go-to therapeutic strategy, but are often tied to resistance.
Triple-negative breast cancer (TNBC) still remains as one of the most aggressive breast cancer types among women, with high metastatic potential and ability to shift towards epithelial-mesenchymal transition (EMT).
Previous research has demonstrated that overexpression or gain-of-function mutations of enhancer of zeste homolog 2 (EZH2) are significantly associated with tumor cell proliferation of a number of cancers.
Chan Zuckerberg Biohub and Stanford University have identified cyclin-dependent kinase 19 (CDK19) inhibitors reported to be useful for the treatment of triple-negative breast cancer.
Korea University Research and Business Foundation (KURBF) has disclosed peptides acting as apoptosis inducers reported to be useful for the treatment of cancer.
