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Home » Topics » Science » Cell therapy

Cell therapy
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Nervous system illustration
Genetic/congenital

Cellatoz’s CLZ-2002 restores nerve myelination in preclinical Charcot-Marie-Tooth disease

May 22, 2024
Many patients with peripheral nerve diseases do not have a sufficient regenerative response because of genetic inheritance, infections or chronic disease, leading them to lifelong pain and disability.
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Human natural killer cell
Immune

FT-522 CAR NK therapy shows dual targeting cytotoxicity, persistence in systemic autoimmunity models

May 17, 2024
Researchers from Fate Therapeutics Inc. presented preclinical data for the multiplexed-engineered, off-the-shelf chimeric antigen receptor (CAR) natural killer (NK) cell therapy, FT-522, as a potential therapeutic against autoimmune diseases.
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3D illustration of tumor
Immuno-oncology

Grant supports Lift Biosciences’ evaluation of IMAN cell therapies in humanized in vivo model systems

May 16, 2024
Lift Biosciences Ltd. has been awarded a grant of over £1 million (US$1.3 million) from Innovate UK that will fund a collaboration between Lift and researchers at the University of Cambridge.
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Immuno-oncology

CD19-specific KIR-CAR T-cell therapy shows efficacy in models of B-cell malignancies

May 13, 2024
Killer immunoglobulin-like receptor (KIR)-chimeric antigen receptor (CAR) T-cell therapies have previously demonstrated superior performance and functional persistence in solid tumor models, and the mesothelin-specific KIR-CAR T cells, Synkir-110, are now being evaluated in phase I trials by Verismo Therapeutics Inc.
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T cells attacking cancer cells
Immuno-oncology

HRYZ-T102, mutated AFP-specific TCR engineered T-cell therapy with improved functionality

May 8, 2024
α-Fetoprotein (AFP) is a tumor-associated antigen and an ideal target for T-cell receptor T-cell (TCR-T) therapy. While the safety of AFP-targeting TCR-T products has been previously demonstrated in early clinical trials, the efficacy of these cell therapies is still modest, warranting further research.
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Natural killer cell attacking cancer cell
Immuno-oncology

IND for Syena’s SY-307 cleared by FDA

April 30, 2024
Replay Holdings LLC and The University of Texas MD Anderson Cancer Center report that the FDA has cleared the IND application for PRAME TCR/IL-15 NK (SY-307), an engineered T-cell receptor natural killer (TCR-NK) cell therapy for relapsed/refractory myeloid malignancies.
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Stem cells
Immune

Tr1x’s TRX-103 to enter phase I following IND clearance

April 11, 2024
The U.S. FDA has cleared Tr1x Inc.’s IND application for TRX-103 for the prevention of graft-vs.-host disease (GVHD) in patients undergoing HLA-mismatched hematopoietic stem cell transplantation (HSCT).
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Immuno-oncology

GC Cell reports data on anti-CD5 CAR-NK therapy with potent efficacy, long-term in vivo persistence in blood

April 11, 2024
A team from GC Cell Corp. reported preclinical data on GL-205, a novel allogeneic anti-CD5 CAR-NK being developed for the treatment of T-cell malignancies. GL-205 was developed using cord blood-derived NK cells that were genetically modified to express CD5-directed CAR and simultaneously produce IL-15 to support NK cell survival and proliferation.
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Endocrine/Metabolic

HIP-engineered islet graft achieves insulin independence without immunosuppression in NHP model

Feb. 16, 2024
It has been hypothesized that allogeneic, hypoimmune (HIP) iPSC-derived or donor-derived islet grafts could provide a new and safe therapeutic alternative for the treatment of type 1 diabetes mellitus (T1DM). Researchers from Sana Biotechnology Inc. and affiliated organizations have published preclinical data from studies further assessing this novel strategy in nonhuman primates (NHPs).
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Endocrine/Metabolic

Autologous B-cell therapy WFX-001 corrects systemic α-GAL enzyme deficiency in vivo

Feb. 14, 2024
Walking Fish Therapeutics Inc. presented a new first-in-class autologous B-cell therapy being developed for the treatment of Fabry disease.
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