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Home » Topics » Clinical

Clinical
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Lungs and bronchi

Insilico progresses AI-discovered drug to phase II trials in idiopathic pulmonary fibrosis

July 20, 2023
By Tamra Sami
Artificial intelligence (AI) drug discovery specialist Insilico Medicine Inc. is progressing INS018-055, its lead compound to phase II trials for idiopathic pulmonary fibrosis, a chronic lung disease that results in progressive and irreversible decline in lung function.
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Flu off the handle: HBV prospects to temper Vir’s phase II bust?

July 20, 2023
By Randy Osborne
Vir Biotechnology Inc. said it won’t be discussing further the phase II data from the influenza A prevention study called Peninsula until the company’s second-quarter earnings update Aug. 3, and a closer look at the results has yet to decide the fate of monoclonal antibody VIR-2482, which missed its primary and secondary endpoints.
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Prostate cancer cells

Study concludes AI-powered biomarker successfully predicts ADT benefits in fighting prostate cancer

July 20, 2023
By David Godkin
ArteraAI Inc. released data from a study it said validates the first-ever artificial intelligence (AI)-derived biomarker predicting the benefit of androgen deprivation therapy (ADT) for stripping prostate cancer of the testosterone it requires to grow.
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Endotheia sees positive results with single-use device for endoscopic surgery

July 19, 2023
By Meg Bryant
Endotheia Inc. reported the successful completion of a first-in-human clinical trial of its steerable technology for endoscopic surgery. The single-use device integrates with standard forward-viewing gastroscopes, allowing physicians to replicate the functions of specialized duodenoscopes that are currently used in the treatment of biliary disease.
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3D illustration of a nerve cell

Argenx sticks to its knitting in CIDP as phase II Adhere data fit Wall Street just right

July 18, 2023
By Randy Osborne
Argenx SE’s top-line results from the phase II Adhere study with Vyvgart Hytrulo (efgartigimod alfa plus hyaluronidase-qvfc) in chronic inflammatory demyelinating polyneuropathy (CIDP) sparked buzz about other developers in the space with similar mechanisms of action to Vyvgart Hytrulo, such as Immunovant Inc.
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Close up of man's eye

Apellis stock flops on retinal vasculitis reports with newly launched Syfovre

July 18, 2023
By Caroline Richards
Apellis Pharmaceutical Inc.’s shares nosedived by 37% July 17 after the American Society of Retina Specialists wrote to ophthalmologists warning them of the risk of serious intraocular inflammation events in patients following injection of the company’s geographic atrophy drug, Syfovre (pegcetacoplan).
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Lilly’s phase III of donanemab in Alzheimer’s slows decline

July 18, 2023
By Lee Landenberger
Strong and complete phase III results for Eli Lilly and Co.’s donanemab for treating early Alzheimer's disease (AD) will no doubt inspire more comparisons with recently approved Leqembi (lecanemab). The newly released data for donanemab show it significantly slowed cognitive and functional decline for those with amyloid-positive early symptomatic AD, which lowered the disease-progression risk.
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Camurus’ acromegaly drug’s appeal grows on strong phase III readout

July 17, 2023
By Caroline Richards
Camurus AB’s subcutaneous octreotide hydrochloride injection pen, CAM-2029, yielded statistically significant improvements in “multiple endpoints” in a 52-week phase III extension trial in patients with acromegaly, moving it closer to providing a more convenient treatment option for patients with the rare, chronic growth disorder than currently available therapies.
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Bridgebio’s acoramidis wows in phase III; NDA filing by year-end 2023

July 17, 2023
By Jennifer Boggs
While the 12-month data from Bridgebio Pharma Inc.’s phase III ATTRibute-CM study testing acoramidis in transthyretin amyloid cardiomyopathy were deemed “puzzling” in late 2021, the 30-month results reported July 17 proved far more pleasing to investors. The trial hit all its endpoints and showed promising results on exploratory markers, sending company shares (NASDAQ:BBIO) up 76%, to close at $32.04, up $13.82.
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Cognito headset

Know what? Cognito study shows gamma therapy reduces Alzheimer’s biomarkers

July 17, 2023
By Annette Boyle
A study conducted by Cognito Therapeutics Inc. demonstrated significant changes in white matter volume and myelination in patients with Alzheimer’s disease after six months of at-home, non-invasive gamma stimulation therapy in a presentation at the Alzheimer’s Association International Conference 2023.
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