The U.S. FDA has granted orphan drug designation to Dewpoint Therapeutics Inc.’s DPTX-3186, its first-in-class condensate modulator for the treatment of gastric cancer. The designation follows the recent opening of Dewpoint’s IND application for DPTX-3186 earlier in October, and is the first orphan designation ever granted to a condensate-modulating therapeutic.
Researchers at Zhejiang University and Zhongshan Institute for Drug Discovery have discovered phosphatidylinositol 3-kinase δ (PI3Kδ) and mammalian target of rapamycin (mTOR; FRAP1) dual inhibitors reported to be useful for the treatment of cancer, infections, autoimmune diseases, cardiovascular diseases, inflammatory disorders and neurological conditions.
Jiangsu Hengrui Pharmaceuticals Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have divulged dihydrofuro[3,4-f]quinazoline compounds acting as GTPase KRAS mutant inhibitors reported to be useful for the treatment of cancer.
Inventisbio Co. Ltd. and Inventisbio LLC have synthesized phosphatidylinositol 3-kinase α (PI3Kα) E542K mutant inhibitors reported to be useful for the treatment of cancer, PIK3CA-related overgrowth spectrum (PROS) and congenital lipomatous overgrowth, vascular malformations, epidermal naevi and skeletal abnormalities (CLOVES syndrome).
China Resources Pharmaceutical Research Institute (Shenzhen) Co. Ltd. has disclosed heterocyclic compounds acting as protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
Various derivatives of α-D-tocopherol (vitamin E) have shown antitumor potential by inhibiting metabolic processes in mitochondria, which nevertheless raises the risk of systemic toxicity. In an approach designed to inhibit such processes in a more targeted fashion, researchers at Yonsei University College of Medicine prepared from α-D-tocopherol a malonate derivative and a primary amide.
The DeGregorio Family Foundation, with support from the Esophageal Cancer Awareness Association, has awarded an additional $75,000 Michael F. Price Memorial Grant to support research that will provide the groundwork to advance two new drugs – SSTN-302 and SST-1034 – to a phase I clinical trial in patients with advanced upper gastrointestinal cancer.
Cyclin-dependent kinases (CDKs) are interesting targets in metastatic cancers. Oncobone Therapeutics Ltd. recently presented data on a new CDK9/13 dual inhibitor – OBP-004 – as a potential approach for treating metastatic cancers.
CDR-609 is a T-cell engager therapeutic from CDR-Life Inc. that targets Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) with potential for treating colorectal cancer.
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