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BioWorld - Saturday, December 9, 2023
Home » Topics » Cancer, BioWorld Asia

Cancer, BioWorld Asia
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Glass vials with radioactive label
Radioactive revolution

Radiopharma pipeline gathers atomic speed

April 11, 2023
By Tamra Sami
No Comments
The radiopharma field has garnered increasing attention in recent years due to big-ticket deals like Bayer AG's $2.9 billion acquisition of Algeta ASA and Novartis AG's nearly $6 billion spent on buying Advanced Accelerator Applications SA and Endocyte Inc. As a result, competition is ratcheting up and pipelines are exploding with new combinations of different drugs. The global radiopharmaceuticals market was estimated to be valued at $6.7 billion in 2020, a number expected to reach $11.5 billion by 2027, according to a 2022 William Blair report.
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Regulatory icons
Radioactive revolution

Keeping up with the technology a growing task for regulators

April 11, 2023
By Mari Serebrov
No Comments
The possibilities of cures for cancer and other tough-to-treat diseases and the ability to further personalize medicine are creating a lot of excitement about the future of radiopharmaceuticals as both therapy and diagnostics. To reach that future, industry and researchers will have to overcome a lot of challenges, not the least of which stem from the multiple government agencies involved in regulating the source material, development, distribution and use of radioactive drugs and devices.
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High Flux Reactor in the Netherlands
Radioactive revolution

Radiopharma industry grapples with supply challenges

April 11, 2023
By Tamra Sami
No Comments
Radiopharmaceuticals require sophisticated infrastructure, with just-in-time radioactives delivered to patients who must isolate while receiving the therapy. Quality control and numerous layers of regulation makes for a daunting space to enter.
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Radioactive revolution

How are radiopharma companies managing supply challenges?

April 11, 2023
By Tamra Sami
No Comments
Supply issues are a “major concern for the whole industry and for the medical community as well, because they see targeted radiotherapy as a very promising field with very interesting results in the clinic, but they are concerned that drugs may not be available for a large number of patients, and it is a legitimate concern,” Orano Med SAS CEO Julien Dodet said.
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Radiotherapy of cancer
Radioactive revolution

How equipped are radiopharma stakeholders to overcome radioactive challenges?

April 4, 2023
By Tamra Sami
No Comments
Global interest in radiopharmaceuticals is growing, and some big deals in the space have sparked interest in the last few years. Novartis AG has spent about $6 billion in acquisitions and is seen as the global leader.
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Radioactive revolution

Scientifically, radioligands may head from bedside back to bench

April 4, 2023
By Anette Breindl
No Comments
If its challenges can be overcome, radioligand therapy is poised to change the way many cancers are treated. It is also likely to become an example of how scientific advances, once they are translated successfully, can enable further insights in a bench-to-bedside-to-bench loop. David Piwnica-Worms, professor and chair of cancer systems imaging at The University of Texas MD Anderson Cancer Center, predicted that as radioligand therapy expands, many questions will be answered about both radiation biology and the interaction of radiation with the immune system more specifically.
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Woman receiving radiotherapy treatments for cancer
Radioactive revolution

Disrupting the oncology space

April 4, 2023
By Tamra Sami
No Comments
After spending decades developing targeted chemotherapy and bringing a dozen or so compounds into the clinic, Fusion Pharmaceuticals Inc. Chief Scientific Officer Christopher Leamon switched careers to focus on radio-oncology because he saw the need for “a really strong bomb to target cancer to get it to respond.” That was radiotherapy, said Leamon, who was one of the scientific founders of Endocyte Inc., which Novartis AG acquired.
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Junshi, Rxilient form JV to develop and commercialize PD-1 toripalimab across Southeast Asia

April 4, 2023
By Tamra Sami
No Comments
Junshi Biosciences Co. Ltd. and Rxilient Biotech Pte Ltd. are forming a joint venture (JV) to develop and commercialize Junshi’s PD-1 inhibitor, toripalimab, in nine Southeast Asian nations.
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Gastric cancer

Astellas’ Claudin 18 inhibitor zolbetuximab meets endpoints in phase III Glow trial

March 28, 2023
By Tamra Sami
No Comments
Astellas Pharma Inc.’s zolbetuximab, a monoclonal antibody targeting Claudin 18.2, met the primary endpoint for progression-free survival as well as secondary endpoints for overall survival in the phase III Glow trial in CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.
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NMPA accepts enfortumab vedotin application from Astellas

March 21, 2023
By Doris Yu
No Comments
The NMPA accepted a BLA from Astellas Pharma Inc. for enfortumab vedotin, which is designed for the treatment of patients with locally advanced or metastatic urothelial cancer who previously received treatment with a PD-1/L1 inhibitor and platinum-based chemotherapy.
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