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BioWorld - Thursday, June 19, 2025
Home » Topics » Cancer, BioWorld Asia

Cancer, BioWorld Asia
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3d rendering of bispecific antibodies

Newco Prolium licenses antibody from Innocare, Keymed for $520M

Jan. 21, 2025
By Tamra Sami
In another Chinese newco out-licensing deal, Innocare Pharma Ltd. and Keymed Biosciences Co. Ltd. out-licensed their co-developed CD20×CD3 bispecific antibody (ICP-B02/CM355) to startup Prolium Bioscience Inc. in a deal worth up to $520 million.
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Newco Timberlyne in-licenses Keymed’s CD-38 MAb for $337M

Jan. 14, 2025
By Tamra Sami
Mountainfield Venture Partners and Chengdu, China-based Keymed Biosciences Co. Ltd have partnered to form San Diego-based Timberlyne Therapeutics, which will progress Keymed’s CD-38 monoclonal antibody globally excluding China.
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Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC

Jan. 14, 2025
By Marian (YoonJee) Chu
Yuhan Corp., Oscotec Inc. and Genosco Inc. were three companies with Asian ties to reap benefit from Johnson & Johnson’s stellar top-line Mariposa study results, wherein J&J’s Rybrevant (amivantamab-vmjw) and Lazcluze (lazertinib) combo regimen beat out Astrazeneca plc’s standard of care in non-small-cell lung cancer (NSCLC).
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Illustration of cell receptors, antibodies

Abbvie and Simcere enter a $1B T-cell engager deal

Jan. 14, 2025
By Lee Landenberger
Abbvie Inc. and Simcere Zaiming Pharmaceutical Co. Ltd. are part of the volley of large deals accompanying the opening of the 43rd annual J.P. Morgan Healthcare Conference in San Francisco. The two have agreed to develop SIM-0500, a humanized GPRC5D-BCMA-CD3 trispecific antibody, which is in phase I studies in the U.S. and China to treat refractory multiple myeloma.
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Green approved stamp

CSPC wins China clearance of new DPP-4 inhibitor

Jan. 14, 2025
By Marian (YoonJee) Chu
CSPC Pharmaceutical Group Ltd. on Jan. 13 gained the National Medical Products Administration’s approval of Shanzeping (prusogliptin tablets; DBPR-108) as a novel oral dipeptidyl peptidase-IV (DPP-4) inhibitor to treat adult patients with type 2 diabetes.
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Glass vial production line

Taiwan’s Tanvex receives second CRL for Herceptin biosimilar

Jan. 7, 2025
By Tamra Sami
Tanvex Biopharma Inc. said its U.S. subsidiary, Tanvex Biopharma U.S.A. Inc., received an FDA complete response letter (CRL) on Jan. 3 for its TX-05 BLA, a biosimilar that references Roche AG’s Herceptin (trastuzumab). The CRL cites unnamed issues that need to be addressed by the downstream manufacturer of TX-05, which is a third-party service provider of Tanvex U.S. for its drug product.
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Deal handshake with coin, chart background

New year, new $1B deal: Roche taps Innovent for new DLL3 ADC drug

Jan. 7, 2025
By Marian (YoonJee) Chu
Roche Holding AG kicked off the new year (again) with a potential $1 billion deal, including $80 million up front, for exclusive rights to Innovent Biologics Inc.’s IBI-3009, a DLL3-targeting antibody-drug conjugate (ADC) candidate that recently entered a phase I study.
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Avenzo, Duality ink $1B-plus tie to advance bispecific ADC

Jan. 7, 2025
By Randy Osborne
The antibody-drug conjugate (ADC) arena continues to ring up deals, as Avenzo Therapeutics Inc. signed an exclusive license agreement with Duality Biotherapeutics Inc., whereby Avenzo will develop, manufacture and commercialize AVZO-1418/DB-1418, described as a potential best-in-class EGFR/HER3 bispecific ADC, globally (excluding greater China).
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Antibody-drug conjugate

Ideaya, Hengrui join hands in $1B deal for phase I ADC targeting DLL3

Dec. 31, 2024
By Tamra Sami
In a deal worth up to $1 billion, Ideaya Biosciences Inc. is in-licensing Jiangsu Hengrui Pharmaceuticals Co. Ltd.’s SHR-4849, a phase I DLL3-targeting opo-I-payload antibody-drug conjugate (ADC). Under terms of the deal, San Francisco-based Ideaya will develop and commercialize SHR-4849 worldwide outside of greater China, and Shanghai-based Hengrui is eligible to receive up to $1.04 billion that includes a $75 million up-front fee, $200 million in development and regulatory milestone payments, and commercial success-based milestone payments. Hengrui is also eligible to receive royalties on net sales outside of greater China.
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Year in review 2024 - Asia deals and innovation

Major 2024 licensing deals confirm Asia’s ascent from copier to innovator

Dec. 31, 2024
By Tamra Sami and Marian (YoonJee) Chu
From local drug discovery to global innovation, economic uncertainty is taking a toll on China’s innovative biotech system, forcing local companies to weather unpredictable storms, investors said during the Chinabio Partnering Forum in Shanghai in September.
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