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Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
Endocrine/metabolic RSS Feed RSS

Kidney disease illustration

Prokidney produces positive phase II CKD data, thunderous stock surge

July 8, 2025
By Lee Landenberger
No Comments
A mixed bag of top-line phase II data prompted stellar stock results for Prokidney Corp. and its chronic kidney disease (CKD) and diabetes therapy, rilparencel. The results came from two arms of the study, each with its own treatment regime. The market heartily took to the results as the company’s stock (NASDAQ:PROK) closed 515% upward at $3.73 per share after starting the day under $1 each.
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Wuhan Healthgen gets chance at China IPO with SSE market reforms

July 7, 2025
By Marian (YoonJee) Chu
No Comments
Wuhan Healthgen Biotechnology Co. Ltd. gained clearance from the Shanghai Stock Exchange July 1 to list under a recently reinstated IPO growth tier geared towards supporting “unprofitable” biotechnology firms.
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Peptide illustration
Endocrine/metabolic

Insparin, a promising antidiabetic peptide

July 4, 2025
No Comments
Insparin is a protein isolated from human adenovirus Ad36 that induces cellular glucose uptake without impacting safety. A preclinical study of insparin looked at its potential antidiabetic effects compared to those of pioglitazone.
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Pills, bottle, scale and-measuring tape
Endocrine/metabolic

Eccogene’s ECC-4703 leads to greater weight loss in preclinical studies

July 3, 2025
No Comments
Glucagon-like peptide 1 receptor (GLP-1R) agonism is a validated approach for treating obesity. ECC-4703 is a small molecule and liver-targeting compound developed by Eccogene Co. Ltd. It is an agonist of thyroid hormone receptor β (THR-β) and its metabolic impact on preclinical models of obesity in combination with semaglutide was investigated.
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Endocrine/metabolic

New GPR40 agonists disclosed in Cascade Pharmaceuticals patent

July 2, 2025
Cascade Pharmaceuticals Inc. has divulged free fatty acid receptor 1 (FFAR1; GPR40) agonists reported to be useful for the treatment of diabetes.
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Woman measuring her body fat with caliper
Endocrine/metabolic

ASC-47 shows superior weight loss effect compared to semaglutide

July 2, 2025
No Comments
ASC-47 is a thyroid hormone receptor β agonist, muscle-preserving weight loss compound for treating obesity developed by Ascletis Pharma Inc. ASC-47 demonstrated a half-life of 26 and 40 days in healthy subjects and in patients with obesity, respectively.
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Feet on scale and measuring tape
Endocrine/metabolic

Protagonist selects GLP-1/GIP/GCG receptor agonist peptide for obesity

July 2, 2025
No Comments
Protagonist Therapeutics Inc. has nominated PN-477 as a development candidate for the treatment of obesity.
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Lei Qian, clinical vice president, Innovent

Innovent raises HKD$4.3B to advance R&D pipeline, global expansion

July 1, 2025
By Tamra Sami
No Comments
Innovent Biologics Inc. announced a HKD$4.3 billion (US$547 million) placement on the Hong Kong Stock Exchange to advance its R&D projects and to fund its global expansion.
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Man measuring waist
Endocrine/metabolic

BI-4659 reverses diet-induced obesity in mice

July 1, 2025
No Comments
Therapies based on glucagon-like peptide 1 (GLP-1) are the most effective for treating obesity to date, but their efficacy and tolerability are limited by gastrointestinal side effects and compensatory reduction of energy expenditure.
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Light micrograph and 3D illustration of adipose tissue.
Endocrine/metabolic

TLC-1180 supports durable weight loss and metabolic gains in combination approaches

July 1, 2025
No Comments
Synthetic mitochondrial protonophores uncouple ATP production, increasing tricarboxylic acid (TCA) cycle activity and fat oxidation to meet energy demands. This approach promotes weight loss and may also enhance glycemic control and lipid metabolism.
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