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Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Obesity, fat cell research concept image
Endocrine/metabolic

Ibio nominates IBIO-610 as obesity development candidate

June 17, 2025
No Comments
Ibio Inc. has nominated IBIO-610 as a development candidate for its first-in-class Activin E antibody program and initiated a nonhuman primate (NHP) study.
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Tape measure, apple on scale
Endocrine/metabolic

MBX Biosciences files IND application for MBX-4291 for obesity

June 17, 2025
No Comments
MBX Biosciences Inc. has submitted an IND application to the FDA for MBX-4291, a long-acting glucagon-like peptide-1 (GLP-1)/ glucose-dependent insulinotropic polypeptide (GIP) receptor co-agonist prodrug for the treatment of obesity.
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Kidneys
Endocrine/metabolic

ISG15 elevation induces diabetic kidney disease, study finds

June 17, 2025
No Comments
Diabetic kidney disease (DKD) is a chronic complication of type 1 and type 2 diabetes with albuminuria and progressive kidney failure; about 20%-40% of patients with diabetes will develop some type of kidney disease.
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Endocrine/metabolic

Haisco Pharmaceutical patents new GLP-1R agonists

June 13, 2025
Haisco Pharmaceutical Group Co. Ltd. has disclosed compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of diabetes and obesity.
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Red blood cells, artery
Endocrine/metabolic

Combining piperine and BCTC into a single drug to treat hyperuricemia

June 13, 2025
No Comments
In gout, excessive levels of uric acid in the blood lead to deposition of urate crystals in joints, which can cause strong inflammatory pain. Effectively treating gout involves mitigating not only the pain due to inflammatory responses, but also reducing uric acid levels in the blood, such as by inhibiting the uric acid transporter URAT1.
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Overweight man sitting on bed facing the window
Endocrine/metabolic

A CD47-blocking antibody ameliorates obesity and enhances exercise capacity

June 11, 2025
No Comments
Obesity is a major public health concern, and effective treatments are still elusive. AMP-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis and has been proposed as a target for metabolic diseases, including obesity. However, most available AMPK agonists target multiple tissues to activate AMPK, which can cause adverse effects.
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Endocrine/metabolic

Lilly patents RXFP1 agonists

June 10, 2025
An Eli Lilly & Co. patent describes new relaxin receptor 1 (RXFP1; LGR7) agonists potentially useful for the treatment of diabetes, stroke, atherosclerosis and more.
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Metsera’s long-acting amylin analogue delivers in phase I

June 9, 2025
By Jennifer Boggs
No Comments
One of the big questions going into the phase I readout for Metsera Inc.’s amylin analogue, MET-233i, was whether findings would support once-monthly dosing for the potential obesity candidate. They did. Results also indicated solid and dose-dependent weight loss activity, and Metsera was able to identify well-tolerated starting doses for subsequent studies, said Steve Marso, chief medical officer. “So we exceeded expectations on all three scientific objectives.”
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Feet and scale
Endocrine/metabolic

Bioage advances apelin receptor agonist program with option to Jikang’s nanobody

June 4, 2025
No Comments
Bioage Labs Inc. is advancing its apelin receptor (APJ) agonist programs for obesity and other indications, and has entered into an option agreement with Jikang Therapeutics to license a novel APJ agonist nanobody.
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Handshake with DNA, molecules

Regeneron boosts obesity pipeline with Hansoh’s GLP-1/GIP for $2B

June 3, 2025
By Tamra Sami
No Comments
Regeneron Pharmaceuticals Inc. is adding to its obesity pipeline by in-licensing Hansoh Biomedical Co. Ltd.’s phase III dual glucagon-like peptide 1 (GLP-1)/gastric inhibitory polypeptide (GIP) receptor agonist, HS-20094, for up to $2 billion.
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