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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Endocrine/Metabolic

Endocrine/Metabolic
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Illustration of sperm racing toward egg
Endocrine/Metabolic

Discovery of a selective inhibitor confirms the role of SLO3 K+ channel in human sperm capacitation

Feb. 9, 2023
No Comments
Membrane hyperpolarization occurs in sperm during the fertilization of an oocyte in both mice and humans.
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A microscopic image of liver tissue affected by nonalcoholic fatty liver disease.
Gastrointestinal

VEGF-B antagonism as a therapeutic strategy against NAFLD

Feb. 8, 2023
No Comments
Insulin resistance in type 2 diabetes (T2DM) is associated with hepatosteatosis and the development of nonalcoholic fatty liver disease (NAFLD), with the pathogenesis of NAFLD being complex and involving the crosstalk between the liver and white adipose tissue (WAT).
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Endocrine/Metabolic

Fusion protein has metabolic benefits in mice, primates

Feb. 8, 2023
By Mar de Miguel
No Comments
Treatment with the fusion protein QL-1005 reduced caloric intake and body weight in mice and primates. In obese animals, it also improved insulin, fasting glucose and triglyceride levels. The design belongs to the Chinese biopharmaceutical company Beijing QL Biopharmaceutical, which will begin clinical trials in a year.
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Endocrine/Metabolic

Novo Nordisk describes new CRF2 receptor agonists for obesity and type 2 diabetes

Feb. 7, 2023
No Comments
Novo Nordisk A/S has identified novel fatty acid modified urocortin 2 derivatives acting as CRF2 receptor agonists reported to be useful for the treatment of obesity and type 2 diabetes.
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Diagram of how cells take up glucose from the stomach and insulin from the pancreas
Endocrine/Metabolic

ALDH1A3 inhibition restores β-cell dysfunction in diabetes

Feb. 7, 2023
No Comments
Insulin secretion by pancreatic β cells is a fundamental component of glucose homeostasis. Aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a molecule involved in pancreatic β-cell dedifferentiation, leading to cell failure, and a marker of type 2 diabetes progression.
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Fertility art concept
Endocrine/Metabolic

FER1L5 is indispensable for acrosome reaction and male fertility in mice

Feb. 7, 2023
No Comments
Ferlins are a family of single transmembrane proteins with multiple calcium ion (Ca2+) binding C2 domains involved in Ca2+-mediated membrane fusion. Among other processes, ferlins participate in the acrosome reaction occurring before spermatozoa fuse with eggs. Mutations in ferlins have been shown to cause male infertility in Caenorhabditis elegans and Drosophila melanogaster.
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3D chemical structure of uric acid.
Endocrine/Metabolic

Discovery of XOR inhibitors with uric acid-lowering activity

Feb. 6, 2023
No Comments
Researchers from South China University of Technology and Chengde Medical University presented the discovery and preclinical evaluation of novel xanthine oxidoreductase (XOR) inhibitors as potential uric acid-lowering agents.
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Illustration of diabetic foot ulcer, cross section of wound
Endocrine/Metabolic

Reactivation of fetal protein can lead to improved diabetic wound healing

Feb. 3, 2023
By Subhasree Nag
No Comments
Researchers at Indiana University School of Medicine are exploring avenues to heal wounds by identifying proteins that are active in fetuses, but largely inactive in adults and absent in diabetic adults. They have identified a protein called nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase, or NPGPx, that fits the bill and could be the basis for therapies aimed at diabetic wound healing. NPGPx is a direct transcriptional target of miR-29. miR-29 is downregulated in fetal tissue, thus NPGPx is active in fetal tissue but becomes mostly inactive in the skin after birth.
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Illustration of diabetic foot ulcer, cross section of wound
Endocrine/Metabolic

Reactivation of fetal protein can lead to improved diabetic wound healing

Feb. 2, 2023
By Subhasree Nag
No Comments
Researchers at Indiana University School of Medicine are exploring avenues to heal wounds by identifying proteins that are active in fetuses, but largely inactive in adults and absent in diabetic adults. They have identified a protein called nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase, or NPGPx, that fits the bill and could be the basis for therapies aimed at diabetic wound healing. NPGPx is a direct transcriptional target of miR-29. miR-29 is downregulated in fetal tissue, thus NPGPx is active in fetal tissue but becomes mostly inactive in the skin after birth.
Read More
IV drips

FDA lifts clinical hold on Astellas Fortis AAV gene therapy trial in Pompe disease

Jan. 31, 2023
By Tamra Sami
No Comments
The U.S. FDA has lifted the clinical hold on Astellas Pharma Inc.’s Fortis phase I/II trial evaluating AAV gene replacement therapy AT-845 in adults with late-onset Pompe disease.
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