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Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Feet and scale
Endocrine/metabolic

Bioage advances apelin receptor agonist program with option to Jikang’s nanobody

June 4, 2025
No Comments
Bioage Labs Inc. is advancing its apelin receptor (APJ) agonist programs for obesity and other indications, and has entered into an option agreement with Jikang Therapeutics to license a novel APJ agonist nanobody.
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Handshake with DNA, molecules

Regeneron boosts obesity pipeline with Hansoh’s GLP-1/GIP for $2B

June 3, 2025
By Tamra Sami
No Comments
Regeneron Pharmaceuticals Inc. is adding to its obesity pipeline by in-licensing Hansoh Biomedical Co. Ltd.’s phase III dual glucagon-like peptide 1 (GLP-1)/gastric inhibitory polypeptide (GIP) receptor agonist, HS-20094, for up to $2 billion.
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Endocrine/metabolic

Chongqing Pharmaceutical and Yaopharma describe new GLP-1R agonists

June 2, 2025
Researchers at Chongqing Pharmaceutical Research Institute Co. Ltd. and Yaopharma Co. Ltd. have identified glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of obesity, type 2 diabetes and nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH).
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Light micrograph and 3D illustration of adipose tissue.
Endocrine/metabolic

Bioage plans mid-year IND submission for BGE-102 for obesity

May 30, 2025
No Comments
Bioage Labs Inc. has completed IND-enabling studies for BGE-102, a structurally novel, orally available small-molecule NLRP3 inhibitor.
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Endocrine/metabolic

New α1-antitrypsin correctors disclosed in Sub21 patent

May 29, 2025
Sub21 Inc. has divulged α1-antitrypsin (SERPINA1) (Z-mutant) correctors reported to be useful for the treatment of α1-antitrypsin deficiency.
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Woman receiving chemotherapy
Endocrine/metabolic

Kexing’s GB-18 receives IND clearances in China and US for cancer cachexia

May 29, 2025
No Comments
Kexing Biopharm Co. Ltd. has announced IND clearances this month by China’s National Medical Products Administration (NMPA) and the U.S. FDA for GB-18, a biologic product for the treatment of cancer cachexia.
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Endocrine/metabolic

Université de Montréal divulges new compounds for cancer and Menkes disease

May 28, 2025
Université de Montréal has synthesized compounds reported to be useful for the treatment of cancer and Menkes disease.
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Heart and DNA

Houston, a problem: Rocket death in Danon stalls phase II program

May 27, 2025
By Randy Osborne
No Comments
Rocket Pharmaceuticals Inc. CEO Gaurav Shah said his firm is investigating how its gene therapy for Danon disease may have created an “unexpected and paradoxical” effect that led to problems for a phase II patient who ultimately died.
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DNA data illustration
Genetic/congenital

Latus Bio’s LTS-101 is a potential therapeutic approach for Batten disease

May 26, 2025
No Comments
Latus Bio Inc. is developing a new gene therapy, LTS-101, for the treatment of neuronal ceroid lipofuscinosis type2 (CLN2), a form of Batten disease characterized by deficiency in the tripeptidyl peptidase 1 (TPP1) protein that leads to lysosomal dysfunction and neurodegeneration.
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Art concept for mouse model
Drug design, drug delivery & technologies

From mice to big animal models in gene therapy for rare diseases

May 23, 2025
By Mar de Miguel
No Comments
The lack of animal models that mimic human disease impedes the study of many pathologies that still lack treatment beyond symptom relief. This is what has happened so far with PURA syndrome, a rare disorder affecting brain development for which a mouse model has finally been developed. Other times, small and large models exist, but an effective treatment remains elusive, as is the case with Krabbe disease, a fatal disease in children that could be prevented with the advances in gene therapy.
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