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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Endocrine/Metabolic

Endocrine/Metabolic
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Endocrine/Metabolic

Korro Bio and Genevant Sciences partner on RNA editing therapeutic for alpha-1 antitrypsin deficiency

March 8, 2023
No Comments
Korro Bio Inc. and Genevant Sciences Corp. have entered into an agreement to combine Korro's...
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Cholesterol plaque in artery

Junshi Biosciences’ PCSK9 inhibitor, ongericimab, meets primary endpoints in two phase III trials

March 7, 2023
By Tamra Sami
No Comments
Junshi Biosciences Co. Ltd.’s ongericimab, a recombinant humanized anti-PCSK9 monoclonal antibody, met the primary endpoints of reducing the levels of low-density lipoprotein cholesterol in two phase III trials in primary hypercholesterolemia and mixed hyperlipidemia.
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Doctor pointing at liver
Endocrine/Metabolic

Hepatocyte-specific SRSF1 knockout triggers NASH-like pathology in mice

March 7, 2023
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Researchers from the University of Illinois Urbana-Champaign have published data from a study designed to assess the role of serine-arginine-rich splicing factor 1 (SRSF1) in hepatocyte function and survival.
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Bridgebio stock grows on phase II achondroplasia data

March 6, 2023
By Lee Landenberger
No Comments
Positive results from Bridgebio Pharma Inc.’s phase II study of infigratinib in children with achondroplasia, a genetic disease that inhibits bone length and leads to short stature, prompted the company stock to surge. Participants receiving the highest dosage, which was the fifth cohort getting 0.25 mg/kg daily, saw a 3.03-centimeter increase, about 1.19 inch, in their height annually, which produced a “p” value of 0.0022.
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3D rendering of alcohol dehydrogenase
Endocrine/Metabolic

Alcohol-metabolizing enzyme plays role in longevity

March 2, 2023
By Mar de Miguel
No Comments
Scientists at the University of Virginia have discovered an anti-aging mechanism mediated by an enzyme that metabolizes alcohol. Alcohol dehydrogenase, which in Caenorhabditis elegans and yeast replaces the rejuvenating effect of autophagy, would reduce age-associated glycerol levels, also promoting longevity in mice and humans.
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Protein structure illustration of fibroblast growth factor receptor 3.
Endocrine/Metabolic

Tyra to develop FGFR3 inhibitor TYRA-300 for achondroplasia

March 2, 2023
No Comments
Tyra Biosciences Inc. is expanding development of TYRA-300 into achondroplasia based on promising preclinical results from a study conducted in collaboration with the Imagine Institute. A specific mutation in fibroblast growth factor receptor 3 (FGFR3) causes over 97% of achondroplasia.
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Cholesterol plaque in artery

Junshi Biosciences’ PCSK9 inhibitor, ongericimab, meets primary endpoints in two phase III trials

March 1, 2023
By Tamra Sami
No Comments
Junshi Biosciences Co. Ltd.’s ongericimab, a recombinant humanized anti-PCSK9 monoclonal antibody, met the primary endpoints of reducing the levels of low-density lipoprotein cholesterol in two phase III trials in primary hypercholesterolemia and mixed hyperlipidemia.
Read More
Concept art for diabetes, genetics.
Endocrine/Metabolic

Inhibiting THADA shows promise as a strategy for prevention and treatment of T2DM

March 1, 2023
No Comments
THADA (thyroid adenoma associated) is a target gene of chromosomal aberration in thyroid adenomas, which has been previously identified as a type 2 diabetes mellitus (T2DM)-associated gene. Recently, researchers from Shandong University and affiliated organizations investigated the effects of THADA deficiency on glucose homeostasis.
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Illustration of ovaries and uterus with endometriosis
Endocrine/Metabolic

Long-lasting effects by ‘recycled’ antibodies improve endometriosis lesions in primate study

March 1, 2023
By Subhasree Nag
No Comments
A multi-institutional team of researchers has reported the development of an anti-IL-8 antibody against endometriosis using recycling antibody engineering technology. The study confirmed the role of the inflammatory cytokine IL-8 in the development of inflammation and fibrosis in endometriosis and showed that administration of IL-8 antibodies in primate models improved endometriosis pathology.
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A microscopic image of liver tissue affected by nonalcoholic fatty liver disease.
Endocrine/Metabolic

Seed funding at Resalis to support development of ncRNA-based therapeutics for metabolic disease

Feb. 23, 2023
No Comments
Resalis Therapeutics Srl has completed a seed financing round of €10 million (US$10.6 million) to establish a noncoding RNA (ncRNA)-based...
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