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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Endocrine/Metabolic

Endocrine/Metabolic
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Endocrine/Metabolic

Discovery of novel α-glucosidase inhibitors’ hypoglycemic activity

Jan. 31, 2023
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Researchers from the University of Jinan reported on α-glucosidase inhibitors as potential antidiabetic agents.
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Women jogging

As weight loss medicine advances, its relevance recedes

Jan. 30, 2023
By Anette Breindl
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Metabolic health is at an odd juncture. With the advent of glucagon-like peptide (GLP-1) agonists, pharmacologically induced weight loss has matured into a viable therapeutic option at long last. GLP-1R agonists, which are also called incretin mimetics and GLP-1 analogs, are likely to continue their success across multiple areas of medical care. Already, the class has transformed diabetes care, making a splash in weight management, and it may yet do the same for other indications.
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Endocrine/Metabolic

HBM Alpha completes seed financing to advance programs for congenital adrenal hyperplasia and PCOS

Jan. 27, 2023
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HBM Alpha Therapeutics Inc. has completed seed financing to advance its lead programs, novel antibody therapies to treat congenital adrenal hyperplasia (CAH) and polycystic ovary syndrome (PCOS).
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Endocrine/Metabolic

Medi & Gene describes new peptides for diabetes

Jan. 25, 2023
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Medi & Gene Inc. has identified peptides reported to be useful for the treatment of diabetes and diabetic complications.
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Light micrograph and 3D illustration of adipose tissue.
Endocrine/Metabolic

Profiling study identifies metabolism-related smORFs and microproteins related in primary adipocytes

Jan. 24, 2023
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Recent work discovered several microproteins encoded by small open reading frames (smORFs) with biological functions in cell stress and survival, metabolism, and muscle development and function, among others. As an endocrine organ, the adipose tissue secretes different peptides and proteins regulating feeding, energy balance, and thermogenesis.
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Lungs
Endocrine/Metabolic

CCK/CCKAR signaling identified as a new mechanism in obesity-induced airway hyperresponsiveness

Jan. 24, 2023
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Cholecystokinin (CCK) is a peptide hormone found predominantly in the gastrointestinal tract and throughout the central nervous system (CNS), and which has been also shown to stimulate the secretion of calcitonin, insulin and glucagon and to act as a natriuretic kidney peptide. Researchers from Harvard University and affiliated organizations aimed to assess the function of CCK in obesity-induced airway hyperresponsiveness (AHR) and asthma.
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Muscle anatomy illustration of man running
Endocrine/Metabolic

New method enables much more detailed look at exerkines, secreted proteins

Jan. 24, 2023
By Anette Breindl
No Comments
Researchers at the Dana-Farber Cancer Institute have been able to identify proteins that were released from muscles during exercise in relatively small quantities. Using their method, the team was able to demonstrate that the neurotrophic factor prosaposin was produced during exercise. Prosaposin is “a well-known CNS neurotrophic factor, but has never been seen to come out of muscle or fat,” Bruce Spiegelman told BioWorld. Spiegelman is a researcher at the Dana-Farber Cancer Institute and Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School.
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Finger prick
Diagnostics

Microsampling plus multiomics enables mail-order metabolism

Jan. 23, 2023
By Anette Breindl
No Comments
Researchers at Stanford University School of Medicine have developed a method to measure several thousand metabolites, including proteins, metabolites, inflammatory markers such as cytokines and, to a degree, lipids. “It’s like Theranos, except it works,” corresponding author Michael Snyder, director of the Center for Genomics and Personalized Medicine at Stanford Medicine, told BioWorld.
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IV drips

FDA lifts clinical hold on Astellas Fortis AAV gene therapy trial in Pompe disease

Jan. 20, 2023
By Tamra Sami
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The U.S. FDA has lifted the clinical hold on Astellas Pharma Inc.’s Fortis phase I/II trial evaluating adeno-associated virus (AAV) gene replacement therapy AT-845 in adults with late-onset Pompe disease.
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Obesity, fat cell research concept image
Endocrine/Metabolic

Discovery of ATF3 inducer for the prophylaxis and treatment of metabolic syndrome

Jan. 19, 2023
No Comments
Researchers from National Cheng Kung University and Taipei Medical University reported the discovery and biological evaluation of novel activating transcription factor 3 (ATF3) inducers as potential candidates for the management of metabolic syndrome.
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