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BioWorld - Thursday, May 28, 2026
Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Handshake behind digital globe

Everest to acquire Singapore unit of Hasten Bio in $250M deal

April 14, 2026
By Marian (YoonJee) Chu
No Comments
Everest Medicines Ltd. has agreed to acquire a Singapore-based commercial unit of Hasten Biopharmaceuticals (Asia) Ltd. for $150 million up front, gaining market authorization holder rights to 14 marketed products originally developed by Takeda Pharmaceutical Co. Ltd.
Read More
Drug research illustration

Biologics in development outnumber small molecules for the first time

April 14, 2026
By Nuala Moran
No Comments
More than four decades on from the approval of the first biologic drug, the industry has reached a tipping point, and biotech drugs now outnumber small molecules in the global R&D pipeline.
Read More
Open capsule delivering pain relief to body

Abbvie nabs two Nav1.8 pain projects from Haisco in $745M deal

April 14, 2026
By Marian (YoonJee) Chu
No Comments
Abbvie Inc. is buying exclusive rights to develop, manufacture and commercialize two Nav1.8 inhibitors for pain – HSK-55718 and HSK-51155 – from Haisco Pharmaceutical Group Co. Ltd. for $30 million up front and up to $715 million in milestone payments, plus royalties.
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Woman exercising with hand weights
Endocrine/metabolic

Fit and fat: Study shows no such thing as metabolically healthy obesity

April 13, 2026
By Nuala Moran
No Comments
There are new data to chew over in the ongoing controversy about obesity being diagnosed as a disease from a study tracking 157,159 participants in the UK Biobank over 13 years. This shows that even in the absence of any metabolic disturbance such as elevated lipids, high blood pressure or diabetes, there is an increased risk of heart attack, stroke, peripheral arterial disease, heart failure and liver disease in people with a body mass index over 30.
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Endocrine/metabolic

Chengdu Diao Pharmaceutical discloses new apelin receptor agonists

April 13, 2026
Chengdu Diao Pharmaceutical Group Co. Ltd. has patented new 1,2,4-triazole compounds characterized as apelin receptor (APLNR) agonists. As such, they are described as useful for the treatment of obesity, hypertension, pulmonary hypertension, heart failure, diabetes, atherosclerosis, osteoporosis and sarcopenia.
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Illustration of the human body next to a DNA double helix
Endocrine/metabolic

GLP-1R drug response tied to variants in target genes

April 13, 2026
By Xavier Bofill Bruna
No Comments
The development of glucagon-like peptide 1 receptor (GLP-1R) agonists, such as semaglutide and tirzepatide, has been a game changer in the clinical management of overweight and obesity, but there is interpersonal variability in efficacy of these medications for weight loss, as well as in the incidence of undesired side effects. Investigators from the 23andMe Research Institute have shed some light on how variations in the GLP-1R and GIP receptor (GIPR) genes impact their effectiveness and the occurrence of side effects.
Read More
Woman exercising with hand weights

Fit and fat: Study shows no such thing as metabolically healthy obesity

April 10, 2026
By Nuala Moran
No Comments
There are new data to chew over in the ongoing controversy about obesity being diagnosed as a disease from a study tracking 157,159 participants in the UK Biobank over 13 years. This shows that even in the absence of any metabolic disturbance such as elevated lipids, high blood pressure or diabetes, there is an increased risk of heart attack, stroke, peripheral arterial disease, heart failure and liver disease in people with a body mass index over 30.
Read More
Drug research illustration
Drug design, drug delivery & technologies

Biologics in development outnumber small molecules for the first time

April 10, 2026
By Nuala Moran
No Comments
More than four decades on from the approval of the first biologic drug, the industry has reached a tipping point, and biotech drugs now outnumber small molecules in the global R&D pipeline. At the start of the biotech industry, progress was slow. Between 1983 and 1995, the U.S. FDA approved an average of two biologics each year. Now, biologics have taken the lead by the smallest of margins, accounting for 50.1% of drugs in development at the start of 2026, according to the Pharma Annual Review 2026, published by Pharmaprojects, a firm that tracks global pharma R&D.
Read More
Handshake behind digital globe

Everest to acquire Singapore unit of Hasten Bio in $250M deal

April 9, 2026
By Marian (YoonJee) Chu
No Comments
Everest Medicines Ltd. has agreed to acquire a Singapore-based commercial unit of Hasten Biopharmaceuticals (Asia) Ltd. for $150 million up front, gaining market authorization holder rights to 14 marketed products originally developed by Takeda Pharmaceutical Co. Ltd.
Read More
Drug research illustration

Biologics in development outnumber small molecules for the first time

April 9, 2026
By Nuala Moran
No Comments
More than four decades on from the approval of the first biologic drug, the industry has reached a tipping point, and biotech drugs now outnumber small molecules in the global R&D pipeline.
Read More
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