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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
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Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 13, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions.
Read More
Gastrointestinal

Korean scientists divulge new ADAMTS4 inhibitors for hepatic fibrosis

June 13, 2025
Researchers at Gachon University and Seoul National University Hospital have synthesized a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4; aggrecanase-1) inhibitors reported to be useful for the treatment of hepatic fibrosis.
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Gastrointestinal

New LPAM-1 antagonists disclosed in Dice Molecules patent

June 12, 2025
Dice Molecules SV LLC has divulged integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of graft-vs.-host disease, type 1 diabetes, inflammatory bowel disease, colitis and primary sclerosing cholangitis.
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Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 11, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions to analyze the microbiome differences and their effects after transplantation form different intestine areas. The results show how host-microbe mismatches after these interventions could affect gut health.
Read More
Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 10, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions to analyze the microbiome differences and their effects after transplantation form different intestine areas. The results show how host-microbe mismatches after these interventions could affect gut health.
Read More
Gastrointestinal

17β-HSD13 inhibitors described in Astrazeneca patent

June 10, 2025
Astrazeneca AB has reported the identification of 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of nonalcoholic steatohepatitis (NASH; MASH), among others.
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Cancer

Mitotic motor protein Eg5 inhibitor Arry-520 to treat gastric cancer

June 10, 2025
No Comments
Gastric cancer, which is the fifth most frequent cancer globally and the third most frequent cause of cancer-related deaths, can be managed relatively well with existing therapies. Advanced gastric cancer, in contrast, is more difficult to manage.
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Gastrointestinal

Kv1.3 induces alcohol-related liver disease

June 10, 2025
No Comments
Researchers have investigated the role of the voltage-dependent potassium channel Kv1.3 in vivo in a murine model of ethanol-exposed alcohol-related liver disease (ALD).
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Doctor pointing at liver
Gastrointestinal

First-in-class FABP/PPAR multiple modulator disclosed

June 10, 2025
No Comments
Researchers from Guangdong Pharmaceutical University and collaborators reported the discovery of [I], a novel FABP/PPAR multiple modulator aimed at the treatment of metabolic dysfunction-associated steatohepatitis (MASH). MASH is a complex liver disease with limited treatment options.
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Gastrointestinal

New 17β-HSD13 inhibitors disclosed in Astrazeneca patents

June 6, 2025
Astrazeneca AB has divulged 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of alcoholic liver disease, liver fibrosis, cirrhosis, hepatic steatosis, liver inflammation, hepatitis C virus (HCV) infection and liver cancer (hepatocellular carcinoma).
Read More
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