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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
Gastrointestinal RSS Feed RSS

Gastrointestinal

Korean researchers patent new autotaxin inhibitors

May 7, 2025
Scientists at Arontier Co. Ltd. and Korea Research Institute of Chemical Technology have disclosed ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2; autotaxin) inhibitors reported to be useful for the treatment of hepatic steatosis, hepatic fibrosis, cirrhosis, liver failure, hepatitis and liver cancer, among others.
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Gastrointestinal

Plant compound PEITC may mitigate both oxidative stress and inflammation in ulcerative colitis

May 7, 2025
No Comments
Ulcerative colitis, one type of chronic inflammatory bowel disease, is driven by a form of programmed cell death called pyroptosis.
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Kidneys

Dimerix strikes $601M Amicus deal for kidney disease drug DMX-200

May 6, 2025
By Tamra Sami
Dimerix Ltd. sealed an exclusive license agreement with Amicus Therapeutics Inc. for commercialization of its phase III kidney disease candidate, DMX-200, in a deal valued at AU$940 million (US$601.22 million).
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Gastrointestinal

Equillium advancing new AhR modulator

May 2, 2025
No Comments
Equillium Inc. is advancing EQ-504, a potent aryl hydrocarbon receptor (AhR) modulator acquired through the acquisition of Ariagen Inc., a company that was majority owned by Equillium’s largest investor, Decheng Capital.
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Kidneys

Dimerix strikes $601M Amicus deal for kidney disease drug DMX-200

May 1, 2025
By Tamra Sami
Dimerix Ltd. sealed an exclusive license agreement with Amicus Therapeutics Inc. for commercialization of its phase III kidney disease candidate, DMX-200, in a deal valued at AU$940 million (US$601.22 million).
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3D illustration of organoid models in a petri dish
Gastrointestinal

Stem cell-derived liver organoids as a model of fatty liver disease

April 28, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with an estimated prevalence of around 25% worldwide. This chronic liver condition is characterized by lipid deposition in the liver, which can lead to inflammation, scarring and even liver cancer if left untreated.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 25, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations.
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Antibodies illustration
Inflammatory

Granite Bio emerges from stealth with focus on antibodies for inflammatory, autoimmune and fibrotic conditions

April 25, 2025
Granite Bio AG has emerged from stealth with $100 million in series A and B funding and a focus on developing first-in-class antibodies that target the root causes of a variety of inflammatory, autoimmune and fibrotic conditions.
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Illustration of cancer tumor on pancreas
Cancer

PIKfyve enzyme is target to ‘starve’ pancreatic cancer cells

April 25, 2025
By Mar de Miguel
A metabolic vulnerability of pancreatic ductal adenocarcinoma (PDAC) could be used to address this type of cancer that often resists treatments. Scientists at the University of Michigan have discovered that inhibiting the PIKfyve enzyme prevented tumor development and reduced tumor growth by altering the lipid synthesis these cells rely on. The KRAS-MAPK pathway is involved in this process, leading the researchers to suggest that dual inhibitors of PIKfyve and KRAS-MAPK could be an effective therapeutic strategy.
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US FDA reduction-in-force delays response to Vanda

April 23, 2025
By Mari Serebrov
A U.S. FDA CDER official is among the first to say the quiet part out loud in proposing a Sept. 12 deadline for the agency to respond to Vanda Pharmaceuticals Inc.’s request for summary judgment or a hearing on CDER’s refusal to approve tradipitant to treat gastroparesis.
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