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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
Gastrointestinal RSS Feed RSS

Kymera’s phase I data lead big week for STAT6 space

June 4, 2025
By Jennifer Boggs
No Comments
It’s a good week to be working on drugs targeting STAT6. Kymera Therapeutics Inc.’s, KT-621, the first oral STAT6 degrader candidate to enter the clinic, surpassed expectations with impressive safety, pharmacokinetic and biomarker data from a phase I trial, while potential fast-followers from Nurix Therapeutics Inc. and Recludix Pharma Inc. advanced via respective partnerships with Sanofi SA.
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Anatara takes a second look at Garp after phase II IBS miss

June 3, 2025
By Tamra Sami
No Comments
After reporting in April that its gastrointestinal reprogramming product (Garp) failed to meet the primary efficacy endpoint in a phase II trial in irritable bowel syndrome (IBS), Anatara Lifesciences Ltd. conducted a further analysis that shows a positive trend toward efficacy.
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Nibec stock soars 30% on $435M peptide deal with US biotech

June 3, 2025
By Marian (YoonJee) Chu
No Comments
Nibec Co. Ltd. announced May 28 the signing of a potential $435 million license deal for NP-201, its phase II-ready peptide-based pulmonary fibrosis therapy candidate, with an undisclosed U.S.-based biotech company.
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Illustration of intestinal track
Gastrointestinal

First high-potency bivalent agonist targeting mucosal 5-HT4R with enhanced safety

June 2, 2025
No Comments
Several 5-HT4 receptor (5-HT4R) agonists are approved for treating chronic idiopathic constipation (CIC) by stimulating gastrointestinal (GI) motility. Traditional 5-HT4R agonists act systemically, causing central nervous and cardiovascular side effects. In contrast, gut-restricted agonists like prucalopride target the GI tract, reducing these risks.
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Nibec stock soars 30% on $435M peptide deal with US biotech

May 29, 2025
By Marian (YoonJee) Chu
No Comments
Nibec Co. Ltd. announced May 28 the signing of a potential $435 million license deal for NP-201, its phase II-ready peptide-based pulmonary fibrosis therapy candidate, with an undisclosed U.S.-based biotech company.
Read More
Liver
Gastrointestinal

Precision medicine approach identifies culprit in alcohol-associated hepatitis

May 29, 2025
By Anette Breindl
No Comments
Researchers have identified KpsM as a virulence factor in Escherichia coli that was responsible for liver damage in alcohol-associated hepatitis (AH). A small-molecule inhibitor of KpsM reduced liver damage in animal models of AH.
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Anatara takes a second look at Garp after phase II IBS miss

May 28, 2025
By Tamra Sami
No Comments
After reporting in April that its gastrointestinal reprogramming product (Garp) failed to meet the primary efficacy endpoint in a phase II trial in irritable bowel syndrome (IBS), Anatara Lifesciences Ltd. conducted a further analysis that shows a positive trend toward efficacy.
Read More

Cinclus and Zentiva have a plan for reflux in Europe

May 23, 2025
By Lee Landenberger
No Comments
Cinclus Pharma Holding AB has chosen Zentiva k.s. to handle manufacturing and commercialization duties in Europe for linaprazan glurate, which is being developed to treat severe erosive gastroesophageal reflux disease.
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Gastrointestinal

New PKCθ inhibitors disclosed in Evommune patent

May 21, 2025
Evommune Inc. has divulged protein kinase PKCθ inhibitors reported to be useful for the treatment of Crohn’s disease and ulcerative colitis.
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Gastrointestinal

Identification of a deuterated TNF-α inhibitor with potential for treating ulcerative colitis

May 21, 2025
No Comments
Tumor necrosis factor-α (TNF-α) is a key cytokine involved in the pathogenesis of ulcerative colitis (UC), a chronic inflammatory bowel disease, and has emerged as a promising therapeutic target.
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