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BioWorld - Wednesday, December 17, 2025
Home » Topics » Immune, BioWorld Science

Immune, BioWorld Science
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Immune

Dual-antigen mRNA vaccine protects against lethal DBV challenge

Nov. 13, 2025
No Comments
Investigators from the University of Science and Technology of China and RNAlfa Biotech have described a novel mRNA-based vaccine candidate against Dabie Banda virus (DBV), which has fatality rates of up to 30% in some East Asian countries.
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Microbiome illustration
Dental

‘Most complete’ map of oral microbiome enables links to systemic disease

Nov. 13, 2025
By Marian (YoonJee) Chu
No Comments
South Korean researchers led by Lee In-suk of Yonsei University have reported the most complete oral microbiome catalog to date, with more than 72,000 genomes. Detailed in Cell Host & Microbe on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told BioWorld.
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Arthritis pain illustration
Musculoskeletal

QEL-005 restores homeostasis in inflammatory disorders

Nov. 12, 2025
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Quell Therapeutics Ltd. have presented data for QEL-005, a new CAR Treg-based compound that targets CD19 and contains a FOXP3 phenotype lock.
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Immune

NKX-019 induces CD19 depletion in autoimmune disease

Nov. 11, 2025
No Comments
Nkarta Therapeutics Inc. has recently presented data for their allogeneic CAR natural killer (NK) cell therapy, NKX-019, targeting CD19 for treating autoimmune disease through B-cell targeting.
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Illustration of antibodies targeting cancer cell
Immune

Commit Biologics’ complement engager platform studied in NHPs

Nov. 11, 2025
No Comments
Commit Biologics ApS has released promising results from a nonhuman primate (NHP) study demonstrating proof of concept for its proprietary bispecific complement engager (BiCE) platform.
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Immune

Inje University discovers new PDPK1 inhibitors

Nov. 11, 2025
Inje University has described 3-phosphoinositide-dependent protein kinase 1 (PDPK1) inhibitors reported to be useful for the treatment of cancer and autoimmune diseases.
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CRISPR Cas9 illustration
Cancer

Azalea exits stealth to develop its in vivo gene engineering technology

Nov. 10, 2025
By Brian Orelli
No Comments
San Francisco Bay Area researchers from UC Berkeley, UC San Francisco and Stanford University have combined their technologies to create Azalea Therapeutics Inc., a company focused on editing cells in vivo.
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Illustration of a T cell
Immune

CDR-Life’s new dual-targeting T-cell engager

Nov. 10, 2025
No Comments
CDR-Life Inc. has presented data on the preclinical characterization of CDR-111, a CD19/BCMA dual T-cell engager for treating autoimmune diseases.
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Microglia and β-amyloid-plaques
Neurology/psychiatric

Microglia acting like T cells mitigate Alzheimer’s progression

Nov. 10, 2025
By Mar de Miguel
No Comments
In Alzheimer’s disease, microglia act as a double-edged sword. They can either protect the brain or worsen the damage, depending on their activation state. Inflammatory activation harms healthy neurons. However, a study reveals that a special type of microglia expressing specific receptors and behaving like T cells may help mitigate this neurodegenerative condition.
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Immune

Pentacyclic derivatives for autoimmune diseases disclosed in Hansoh patent

Nov. 6, 2025
No Comments
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have divulged pentacyclic derivatives reported to be useful for the treatment of autoimmune disease.
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