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BioWorld - Tuesday, June 24, 2025
Home » Topics » Disease categories and therapies » Nephrology

Nephrology
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
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Kidneys
Endocrine/metabolic

ISG15 elevation induces diabetic kidney disease, study finds

June 17, 2025
No Comments
Diabetic kidney disease (DKD) is a chronic complication of type 1 and type 2 diabetes with albuminuria and progressive kidney failure; about 20%-40% of patients with diabetes will develop some type of kidney disease.
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Illustration of monoclonal antibody hovering between doctor's hands
Nephrology

JADE-101 ameliorates IgA nephropathy features in preclinical setting

June 13, 2025
No Comments
IgA nephropathy is a progressive kidney disease characterized by the deposition of immune complexes containing IgA, where a proliferation-inducing ligand (APRIL) drives the production of pathogenic IgA. Jade Biosciences Inc. has developed a novel APRIL-binding therapeutic, JADE-101, for the treatment of IgA nephropathy.
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Nephrology

Morphic Therapeutic describes new integrin αvβ1 antagonists

June 12, 2025
Morphic Therapeutic Inc. has identified compounds acting as integrin αvβ1 antagonists reported to be useful for the treatment of cancer, chronic kidney disease, diabetic nephropathy, pulmonary arterial hypertension, idiopathic pulmonary fibrosis, interstitial lung diseases, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH) and primary biliary cholangitis.
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Nephrology

Rectify’s RTY-822 improves kidney function and vascular calcification in CKD

June 12, 2025
No Comments
The ionic and metabolic impairment observed in chronic kidney disease (CKD) leads to vascular calcification, which can induce cardiovascular events and mortality. Several factors may impact the progression of vascular calcification, where inorganic pyrophosphate plays a crucial inhibitory role.
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Nephrology

Vertex Pharmaceuticals discovers new PKD1 correctors

June 6, 2025
Vertex Pharmaceuticals Inc. has described polycystin-1 (PKD1) (mutant) correctors reported to be useful for the treatment of autosomal dominant polycystic kidney disease.
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Nephrology

Shanghai Qilu Pharmaceutical divulges new CYP11B2 inhibitors

June 4, 2025
Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has synthesized cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the treatment of hypertension, diabetic nephropathy, chronic kidney disease and primary aldosteronism.
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Illustration showing parts of a kidney nephron
Biomarkers

FFAR4 as biomarker of glomerular injury and aging

June 4, 2025
No Comments
Researchers have discovered that reduced expression of the free fatty acid receptor 4 (FFAR4) is a biomarker of podocyte injury and aging, as well as a therapeutic target. Podocyte injury leads to progression of glomerular disease and aging, but the underlying mechanisms are poorly understood.
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Next IgAN contenders line up; Vera preps a BLA for atacicept

June 3, 2025
By Karen Carey
No Comments
With a 42% placebo-adjusted reduction in proteinuria at week 36, Vera Therapeutics Inc. met its primary endpoint in the Origin phase III trial with BAFF and APRIL dual inhibitor atacicept in treating immunoglobulin A nephropathy (IgAN) in adults.
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