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Home » Topics » Disease categories and therapies » Nephrology

Nephrology
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Therapeutic trends 2024 - GLP-1RAs
Endocrine/metabolic

GLP-1 receptor agonists continue their global victory tour

Dec. 27, 2024
By Anette Breindl
2024 was another banner year for GLP-1 receptor agonists (GLP-1RAs) on multiple fronts. They continued to expand into new indications, and provide their developers with both rich remuneration and scientific acclamation. There are now seven approved GLP-1RAs. Commercially, the most successful one so far is semaglutide, sold under the brand name Wegovy or Ozempic depending on the indication.
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Doctor with illustration of kidneys
Nephrology

Melanin-like nanoparticles inhibit cystogenesis in kidney disease model

Dec. 24, 2024
Autosomal dominant polycystic kidney disease (ADPKD) is a severe genetic disorder primarily caused by mutations in the PKD1 or PKD2 genes, which encode polycystins 1 and 2, affecting over 12 million people globally.
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DNA illustration
Endocrine/metabolic

Arbor gains IND clearance for rare disease gene editing therapy

Dec. 20, 2024
Arbor Biotechnologies Inc. has gained IND clearance from the FDA for ABO-101, a novel gene editing therapeutic designed to address primary hyperoxaluria type 1 (PH1). A phase I/II study in adult and pediatric patients with PH1 is expected to begin in the first half of 2025.
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Kidneys
Nephrology

Evidence of potential utility of RNK-288 siRNA in IgA nephropathy

Nov. 8, 2024
IgA nephropathy is the most common primary glomerulonephritis and contributes to kidney failure. Growing evidence exists that the overactivation of the lectin pathway contributes to the pathogenesis of IgA nephropathy.
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Illustration of diseased kidney
Nephrology

CH-6824025 ameliorates fibrosis, inflammation in kidney disease

Nov. 7, 2024
Although antifibrotic agents can contribute to suppressing renal function decline when administered in combination with existing treatments for chronic kidney disease, drugs targeting kidney fibrosis have yet to reach the clinic.
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Nephrology

ClC-c-deficient Drosophila nephrocyte model for Dent disease

Nov. 6, 2024
Scientists from Universitätsklinikum Heidelberg and affiliated organizations aimed to characterize a novel Drosophila model for Dent disease.
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Kidneys
Nephrology

Silencing HSP27 reduces crescent formation in model of crescentic glomerulonephritis

Nov. 4, 2024
Scientists from INSERM and affiliated organizations presented findings from their work that aimed to investigate the involvement of heat shock protein 27 (HSP27) in the activation and pathological accumulation of parietal epithelial cells (PEC) during crescentic glomerulonephritis (CrGN).
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Neutrophil and red blood cells
Endocrine/metabolic

GDF-15 is therapeutic target in type 2 diabetes sequelae

Oct. 31, 2024
Previous studies have shown that NETosis, a specialized form of neutrophil-specific cell death, is involved in the pathogenesis of diabetes.
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Purple-tinted test tubes and dropper
Nephrology

S1PR4 inhibition prevents disease progression in murine Alport syndrome

Oct. 30, 2024
The knockout of Col4a3 in mice is used as a model of Alport syndrome. Knockout mice develop glomerular disease associated with neutral lipid accumulation in the kidney and progressive renal failure, which can be treated with lipid-lowering agents.
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Kidney Week 2024: Semaglutide tackles another organ

Oct. 29, 2024
By Brian Orelli
Semaglutide, the glucagon-like peptide 1 receptor agonist from Novo Nordisk A/S, which has seemingly improved every disease it’s been tested on, was a focus at Kidney Week 2024, where researchers presented data from multiple clinical studies in patients with kidney diseases.
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