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BioWorld - Thursday, September 28, 2023
Home » Topics » Ocular, BioWorld

Ocular, BioWorld
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Eye and DNA

Cellusion raises $9.5M to support ocular cell therapy

Jan. 12, 2022
By Gina Lee
No Comments
Cellusion Inc. recently closed a ¥1.1 billion ($9.5 million) financing, bringing its total 2021 fundraising to ¥1.7 billion. The company is preparing to enter the clinic with CL-S001, its corneal endothelial substitute cell candidate for treating corneal edema due to endothelial dysfunction, or bullous keratopathy.
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Woman using eyedrops

Aldeyra’s reproxalap not DED yet as Palatin prospect reaches phase III

Dec. 28, 2021
By Randy Osborne
No Comments
With the memory of Dec. 20’s stock-denting, top-line phase III fizzle by Aldeyra Therapeutics Inc. in dry eye disease (DED) still fresh, Palatin Technologies Inc. is launching a late-stage effort in the same indication. Aldeyra offered data from the Tranquility trial with reproxalap – a small-molecule, immune-modulating covalent inhibitor of reactive aldehyde species, known as RASP, formulated as an ophthalmic solution – that showed a miss on the primary endpoint of ocular redness.
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Eye and DNA illustration

$800M up front: Novartis acquiring ocular gene therapy firm Gyroscope for up to $1.5B

Dec. 22, 2021
By Cormac Sheridan
No Comments
DUBLIN – Novartis AG is deepening its commitment to ocular gene therapy by picking up Gyroscope Therapeutics Ltd. for $800 million up front and up to $700 million more in potential milestone payments.
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Eye illustration

Opregen pedigree passes Roche muster, draws $670M deal in dry AMD

Dec. 20, 2021
By Randy Osborne
No Comments
What one analyst called “fantastic external validation but, even more importantly, great for the cell therapy and regenerative medicine space” arrived in the form of Lineage Cell Therapeutics Inc.’s potential $670 million deal with Roche Holding AG. With its subsidiary, Cell Cure Neurosciences Ltd., Lineage signed an exclusive worldwide collaboration and license pact with Roche and its Genentech arm.
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Gold dollar sign inside gold cog

Acelyrin closes $250M series B round, in-licenses Affibody IL-17 inhibitor for $25M up front

Nov. 16, 2021
By Cormac Sheridan
No Comments
Acelyrin Inc. closed a $250 million series B round and, at the same time, unveiled a licensing deal with Affibody AB, involving an interleukin-17A (IL-17A) inhibitor, izokibep, which it is now testing in a pivotal trial in uveitis. Solna, Sweden-based Affibody is getting $25 million up front and could earn up to $280 million more in regulatory and sales-based milestones, as well as tiered royalties, ranging from high single digits to low double digits in percentage terms.
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No need to squint: Abbvie clear first-to-market winner in presbyopia

Nov. 1, 2021
By Randy Osborne
No Comments
Abbvie Inc.’s FDA clearance of Vuity (pilocarpine HCl ophthalmic solution) 1.25% for the treatment of presbyopia in adults, could bring relief to about 128 million Americans: almost half of the U.S. population, the company said. It’s the first and only eye drop given U.S. regulators’ go-ahead for what’s known as age-related blurry near vision – but plenty more have generated clinical data.
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Adamis’ high-dose naloxone clears FDA hurdle at last; Oyster Point wins nod in dry eye

Oct. 18, 2021
No Comments
The third time proved the charm for Adamis Pharmaceuticals Corp.’s high-dose naloxone injection, Zimhi, which gained FDA approval for use in treating opioid overdose, nearly three years after the San Diego-based company first submitted an NDA.
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Eye illustration

Intellia, Sparingvision see new paths to ophthalmology market in partnership

Oct. 14, 2021
By Nuala Moran
No Comments
LONDON – Intellia Therapeutics Inc. is to receive 10% of the equity in Sparingvision SAS as part of a deal giving the French ophthalmology specialist certain exclusive rights to in vivo CRISPR/Cas9 technologies in the treatment of ocular diseases.
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Close-up of elderly eye

Immunocore’s phase III in melanoma shows survival benefit

Sep. 23, 2021
By Lee Landenberger
No Comments
When an independent data monitoring committee told Immunocore Ltd. plc’s David Berman in November that tebentafusp had met a phase III study’s pre-defined boundaries for statistical significance in overall survival (OS) after its first pre-planned interim analysis, the head of R&D was shocked.
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Close-up of elderly eye

Eye copy that: FDA front door for Lucentis biosimilar from Biogen, Samsung

Sep. 20, 2021
By Randy Osborne
No Comments
Biogen Inc. and Samsung Bioepis Co. Ltd. gained FDA clearance for Byooviz (ranibizumab-nuna), a biosimilar that references the VEGF therapy Lucentis (ranibizumab) from Roche Holding AG, as a treatment for wet age-related macular degeneration, macular edema following retinal vein occlusion and myopic choroidal neovascularization. Byooviz is the first ophthalmology biosimilar to win the go-ahead in the U.S., and was approved in the EU on Aug. 18, 2021, followed by the U.K. on Aug. 31, 2021.
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