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BioWorld - Saturday, September 23, 2023
Home » Topics » Drugs » Monoclonal antibody

Monoclonal antibody
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Malaria-infected-red-blood-cell
Infection

Ocean Biomedical outlines programs targeting PfGARP to tackle malaria

July 12, 2023
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Ocean Biomedical Inc. has announced a multi...
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Orthopoxvirus illustration
Infection

US DoD awards Just-Evotec Biologics contract for development of MAbs targeting orthopoxviruses

July 5, 2023
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The U.S. Department of Defense (DOD) has awarded Evotec SE’s subsidiary Just-Evotec Biologics Inc. a contract valued up to US$74 million for the rapid development of monoclonal antibody (MAb)-based drug product prototypes targeting orthopoxviruses.
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Illustration of heart and lung vasculature in pulmonary hypertension vs. normal
Cardiovascular

Zymedi collaborates with NHLBI to advance ZMA-001 for pulmonary arterial hypertension

July 3, 2023
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Zymedi Co. Ltd. has signed a clinical cooperative research and development agreement (CRADA) with the National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), to develop ZMA-001 for the treatment of pulmonary arterial hypertension (PAH).
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Colorized scanning electron microscope image of regulatory T cells and antigen-presenting cells.
Immuno-oncology

Domain Therapeutics nominates CCR8 antibody candidate DT-7012

June 30, 2023
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Domain Therapeutics SA has nominated a novel drug candidate, DT-7012, an anti-CCR8 monoclonal antibody depleting tumor-infiltrating regulatory T cells (Tregs).
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Endocrine/Metabolic

China’s NMPA clears anti-GFRAL monoclonal antibody JMT-203 to enter clinic for cancer cachexia

June 27, 2023
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CSPC Pharmaceutical Group Ltd. has announced clinical trial approval by China’s National Medical Products Administration (NMPA) for the antibody drug JMT-203, being developed by the company’s Shanghai JMT-Bio Technology Co. Ltd. subsidiary for cancer cachexia.
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White blood cells with red blood cells
Hematologic

Iaso’s IASO-782 cleared to enter clinic in US for autoimmune hematological disorders

June 19, 2023
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Iaso Biotechnology Co. Ltd. has received FDA approval of the company’s IND application for IASO-782 injection for use in U.S. clinical trials for autoimmune hematological disorders, including primary immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (AIHA).
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Head and neck anatomy
Immuno-oncology

Alentis Therapeutics’ CLDN1-targeting antibody cleared to enter clinic in US for head and neck cancer

June 15, 2023
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Alentis Therapeutics AG has received FDA clearance of the company’s IND application for ALE.C04, a first-in-class monoclonal antibody developed to specifically target exposed Claudin-1 (CLDN1) on cancer cells.
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Illustration of bones showing difference in Ewing sarcoma, osteosarcoma and chondrosarcoma
Immuno-oncology

Cancervax’s UCLA research team creates monoclonal antibody candidates for Ewing sarcoma

June 13, 2023
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Cancervax Inc. has announced further progress made by its research team at the University of California, Los Angeles (UCLA) toward...
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DNA and antibodies
Infection

Gates Foundation grant supports Aegis Life’s development of DNA-encoded antibodies for infectious diseases

June 8, 2023
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Aegis Life Inc. and its parent company Entos Pharmaceuticals Inc. (Entos) have entered into a grant agreement with the Bill & Melinda Gates Foundation in the area of infectious disease.
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Coronavirus and antibodies
Infection

New multispecific antibody platform offers increased potency and breadth against SARS-CoV-2

June 7, 2023
No Comments
Scientists from the Hospital for Sick Children Research Institute and collaborators have reported the application of a multispecific, multiaffinity antibody (Multabody, MB) platform derived from the human apoferritin protomer to enable the multimerization of antibody fragments against SARS-CoV-2. These MBs showed high potency to neutralize SARS-CoV-2 even at lower concentrations than their corresponding MAb counterparts.
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