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Home » Topics » Drugs » Peptide

Peptide
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Molecule illustration
Immune

Unnatural Products joins Argenx in a $1.5B macrocyclic deal

July 2, 2025
By Lee Landenberger
No Comments
Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and R&D funding, could end up with about $1.5 billion in milestones and options payments plus tiered royalties on net sales.
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Feet on scale and measuring tape
Endocrine/metabolic

Protagonist selects GLP-1/GIP/GCG receptor agonist peptide for obesity

July 2, 2025
No Comments
Protagonist Therapeutics Inc. has nominated PN-477 as a development candidate for the treatment of obesity.
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Molecule illustration

Unnatural Products joins Argenx in a $1.5B macrocyclic deal

July 1, 2025
By Lee Landenberger
No Comments
Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and R&D funding, could end up with about $1.5 billion in milestones and options payments plus tiered royalties on net sales.
Read More
Mazdutide injection device and product packaging

China clears mazdutide as first dual GCG/GLP-1RA for weight loss

June 30, 2025
By Marian (YoonJee) Chu
No Comments
Innovent Biologics Inc. announced June 27 that it gained National Medical Products Administration’s (NMPA) approval of mazdutide as a new weight loss therapy for obese or overweight patients in China. Mazdutide is a dual glucagon/glucagon-like peptide-1 (GCG/GLP-1) receptor agonist originally discovered by Eli Lilly and Co., of Indianapolis.
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Mazdutide injection device and product packaging

China clears mazdutide as first dual GCG/GLP-1RA for weight loss

June 30, 2025
By Marian (YoonJee) Chu
No Comments
Innovent Biologics Inc. announced June 27 that it gained National Medical Products Administration’s (NMPA) approval of mazdutide as a new weight loss therapy for obese or overweight patients in China. Mazdutide is a dual glucagon/glucagon-like peptide-1 (GCG/GLP-1) receptor agonist originally discovered by Eli Lilly and Co., of Indianapolis.
Read More
Elderly hands holding broken brain structure

Xpro phase II miss as Inmune’s Mindful tunes in to AD subgroup

June 30, 2025
By Randy Osborne
No Comments
Inmune Bio Inc. claimed a phase II win with TNF inhibitor Xpro (pegipanermin) in early Alzheimer’s disease (AD), though the study missed its primary and secondary endpoints, leading shares of the firm (NASDAQ:INMB) to close at $2.16, down $3.18, or almost 60%.
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Liver illustration

Altimmune’s phase IIb in MASH hits and misses, stock halves

June 26, 2025
By Lee Landenberger
No Comments
Top-line results from Altimmune Inc.’s phase IIb Impact study of pemvidutide in treating metabolic dysfunction-associated steatohepatitis showed the peptide-based GLP-1/glucagon dual receptor agonist hit one primary endpoint while not hitting statistical significance in another.
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Colorized transmission electron micrograph of SARS-CoV-2 (UK B.1.1.7 variant).
Infection

Researchers develop NSP8-derived peptides successfully targeting SARS-CoV-2 replication machinery

June 16, 2025
No Comments
Researchers from the Institute for Basic Science of Korea and collaborating institutions have designed a new class of peptide-based inhibitors targeting a crucial interface within the SARS-CoV-2 replication complex, offering a potential new avenue for antiviral therapy.
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Metsera’s long-acting amylin analogue delivers in phase I

June 9, 2025
By Jennifer Boggs
No Comments
One of the big questions going into the phase I readout for Metsera Inc.’s amylin analogue, MET-233i, was whether findings would support once-monthly dosing for the potential obesity candidate. They did. Results also indicated solid and dose-dependent weight loss activity, and Metsera was able to identify well-tolerated starting doses for subsequent studies, said Steve Marso, chief medical officer. “So we exceeded expectations on all three scientific objectives.”
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Red blood cells in an artery with cholesterol

In two phase IIIs, Merck’s PCSK9 inhibitor cuts cholesterol

June 9, 2025
By Lee Landenberger
No Comments
In two phase III studies, Merck & Co. Inc.’s oral, once monthly proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor produced statistically significant and clinically meaningful cuts in low-density lipoprotein cholesterol levels. The PCSK9 inhibitor is looking to fit into a crowded market that already has well-established therapies from other big pharmas and a potential competitor in development to treat another indication.
Read More
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