Research at Nanjing Minova Pharmaceutical Co. Ltd. has led to the development of water-soluble allopregnanolone derivatives acting as prodrugs and reported to be useful for the treatment of Alzheimer’s disease, epilepsy, traumatic brain injury, post-traumatic stress, seasonal mood disorder, essential tremor, dysthymia and postpartum depression, among others.
Researchers at Tuojie Biotech (Shanghai) Co. Ltd. have developed substituted 1,4-dihydro-1,6-naphthyridine amides characterized as mineralocorticoid receptor (MR) antagonists and reported to be useful for the treatment of hypertension, aldosteronism and heart failure.
A recent F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. patent describes compounds reported to be useful for the treatment of Escherichia coli infection.
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and Tongji Hospital have disclosed sulfonylurea compounds acting as bifunctional epoxide hydrolase 2 (EPHX2; sEH) inhibitors reported to be useful for the treatment of heart failure.
Montelino Therapeutics LLC has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor variant 7 (AR-v7)-targeting moiety through a linker. They are reported to be useful for the treatment of cancer.
Centre National de la Recherche Scientifique and Université Paul Sabatier - Toulouse III have divulged alkynylcarbinols acting as 17β -hydroxysteroid dehydrogenase 11 (17β-HSD11; 17bHSD11; 17βHSD11)-activated compounds reported to be useful for the treatment of cancer, bacterial, fungal and parasitic infections.
Ubix Therapeutics Inc. has identified proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a protein ENL (MLLT1; YEATS1) targeting moiety via linker.
Shouyao Holdings (Beijing) Co. Ltd. has synthesized DNA-dependent protein kinase (DNA-PK) inhibitors reported to be useful for the treatment of cancer.
Astrazeneca has described spirocyclic compounds acting as protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
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