Galderma Holding SA has identified metabolites of CD-14547 acting as mammalian target of rapamycin (mTOR; FRAP1) inhibitors. As such, they are reported to be useful for the treatment of acne, atopic dermatitis, actinic keratosis and psoriasis.
Nitrogen-containing tricyclic compounds acting as pyruvate dehydrogenase kinase 2 (PDHK2; PDK2) inhibitors have been described in a recent Japan Tobacco Inc. patent. They are reported to be useful for the treatment of diabetes, atherosclerosis, cancer, chronic kidney disease, Alzheimer’s disease, heart failure, pulmonary hypertension and stroke.
Cholesgen (Shanghai) Co. Ltd. has prepared and tested tricyclic diterpene analogues acting as Hedgehog (Hh) signaling inhibitors and apoptosis inducers. As such, they are reported to be useful for the treatment of cancer.
Ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors have been reported in a Simcere Zaiming Pharmaceutical Co. Ltd. patent as potentially useful for the treatment of cancer.
Research at Japan Tobacco Inc. has led to the development of 6-aminopyrazolopyrimidine compounds acting as NLRP3 inflammasome inhibitors and reported to be useful for the treatment of arteriosclerosis, gout, inflammatory bowel disease, amyotrophic lateral sclerosis, multiple sclerosis, nonalcoholic steatohepatitis (NASH), Alzheimer’s and Parkinson’s diseases.
Research at Bristol Myers Squibb Co. has led to the development of [11]-carbon-labeled compounds targeting Bruton tyrosine kinase (BTK) as positron emission tomography (PET) imaging agents for the diagnosis of multiple sclerosis.
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