Celgene Corp. has disclosed sphingosine 1-phosphate receptor 5 (S1PR5; EDG8) modulators reported to be useful for the treatment of Alzheimer's disease and multiple sclerosis.
Gruenenthal GmbH has described substituted pyrazole amides acting as sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain.
Suzhou Spring-Sea Bio-Pharmaceuticals Co. Ltd. has divulged prodrugs of N4-hydroxycytidine (NHC) reported to be useful for the treatment of viral infections.
Tuojie Biotech (Shanghai) Co. Ltd. has identified mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors reported to be useful for the treatment of cancer, inflammation and autoimmune diseases.
National Institute of Pharmaceutical R&D Co. Ltd. has synthesized high affinity nerve growth factor receptor (NTRK1; TRKA) and its mutant inhibitors reported to be useful for the treatment of cancer.
Medshine Discovery Inc. has identified proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to an androgen receptor targeting moiety via a linker acting as androgen receptor degradation inducers reported to be useful for the treatment of cancer.
Minghui Pharmaceutical (Hangzhou) Ltd. and Minghui Pharmaceutical (Shanghai) Ltd. have synthesized antibody-drug conjugates consisting of an antibody covalently linked to exatecan derivatives through a linker.
Shaanxi Panlong Pharmaceutical Group Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) targeting moiety via linker acting as 3CLpro (SARS-CoV-2) degradation inducers reported to be useful for the treatment of SARS-CoV-2 infection.
RSS
