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Home » Topics » Genomics » GWAS

GWAS
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Genetic/congenital

Rockfish lifespan diversity gives insights into human aging GWAS

Jan. 16, 2023
By Anette Breindl
“Short-lived organisms represent a fundamentally different evolutionary strategy, and the idiosyncrasies influencing their aging may not apply to longer-lived models, including humans,” researchers from Harvard Medical School wrote in the Jan. 11, 2023, issue of Science Advances.


In their paper, the authors reported insights into the genomics of longevity that took advantage of an unusual animal model: rockfish.
Read More
Genetic/Congenital

UCLA biobank takes advantage of LA’s diversity

Jan. 12, 2023
By Mar de Miguel
Los Angeles is one of the most diverse cities in the U.S. This diversity is evident at University of California, Los Angeles (UCLA), a university that attracts students (37,000) and workers (22,090) from 118 countries. It is enough to go for a walk on campus or its surroundings to believe that one is at a United Nations convention. Researchers at the UCLA ATLAS Community Health Initiative has been capturing that diversity in a genomic biobank whose data will help to understand, anonymously, the genetic basis of certain diseases. With them, scientists will be able to design the best treatments for these patients.
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Inflammatory

New approach to osteoarthritis identified through GWAS

Jan. 11, 2023
By Nuala Moran
An Icelandic genome-wide association study that linked variants in a gene which regulates retinoic acid synthesis to severe osteoarthritis (OA) of the hands, has led on to the discovery of an anti-inflammatory role for the vitamin A metabolite and pointed to a new class of potentially disease-modifying drugs. A proof-of-concept clinical trial of talarozole, a retinoic acid metabolism blocking agent, is now taking place to assess if increasing retinoic acid production suppresses inflammation in the joint tissues of patients with OA.
Read More
DNA illustration
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 24, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize the understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
Read More
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 23, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
Read More
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