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BioWorld - Thursday, December 4, 2025
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BioWorld Science, Infection
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3D illustration showing surface glycoprotein spikes hemagglutinin (purple) and neuraminidase (orange)
Immune

Grant supports evaluation of Auravax’s Nanosting-001

Sep. 16, 2025
No Comments
Auravax Therapeutics Inc. has received funding from the Gates Foundation to evaluate the efficacy of Nanosting-001 in validated swine models of influenza infection at Kansas State University College of Veterinary Medicine and The Pirbright Institute.
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mRNA vaccines are composed of messenger RNA encapsulated in lipid nanoparticles
Drug design, drug delivery & technologies

Animosity toward mRNA COVID vaccines puts basic science at risk

Sep. 16, 2025
By Mar de Miguel
No Comments
An ongoing concern for scientists is that there will be across-the-board funding cuts. This is already happening in mRNA research, where reductions affected coronavirus-related projects. During the pandemic, efforts focused on this pathogen, and once the health emergency was over, grants for antivirals were eliminated. However, these drugs could stem future outbreaks. Despite the cuts, recent research continues to demonstrate the potential of mRNA, not only for the development of antivirals, but also for obtaining more effective and longer-lasting vaccines.
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Infection

Harvard College divulges new compounds to treat SARS-CoV-2

Sep. 15, 2025
Harvard College has published compounds reported to be useful for the treatment of SARS-CoV-2 infections (COVID-19).
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Colorized scanning electron micrograph of human respiratory syncytial virus.
Infection

CSPC’s SYH-2066 gains trial clearance in China for RSV

Sep. 15, 2025
No Comments
CSPC Pharmaceutical Group Ltd.’s SYH-2066 tablets has obtained clearance from China’s National Medical Products Administration (NMPA) to enter clinical trials for respiratory infections caused by respiratory syncytial virus (RSV).
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Infection

Merck’s MK-8527 enables long-acting HIV-1 prevention

Sep. 15, 2025
No Comments
Nucleoside reverse transcriptase translocation inhibitors (NRTTIs) are a novel class of antiretroviral agents that inhibit HIV replication by targeting the viral reverse transcriptase enzyme and specifically blocking its translocation step during DNA synthesis, a critical process in the viral replication cycle.
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Vial and syringe in row of dominoes
Drug design, drug delivery & technologies

The domino effect of cutting mRNA vaccine research

Sep. 15, 2025
By Mar de Miguel
No Comments
In August, a press release from HHS announced the cancellation of 22 vaccine research projects based on mRNA, the latest available technology aimed at developing therapies for viral infections, cancer, and genetic conditions. What happens to mRNA innovation when funding dries up? This series explores how reductions in funding could impact mRNA technology, affecting innovation, research and future therapies.
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Lasker award winners 2025
Drug design, drug delivery & technologies

Lasker Awards honor the fine compartmentalization of life

Sep. 12, 2025
By Mar de Miguel
A tangle of DNA can look like a knotted ball in the cell nucleus. However, the genetic machinery has a complex and regulated structure. Its long repetitive sequences also seemed to have no function. They were called junk DNA, although they were not. The same happened with proteins and low-complexity domains, disordered chains of amino acids that were poorly understood. Nevertheless, that protein noise has turned into music for the 2025 Lasker Awards. These prizes have recognized the work of scientists who were able to see order in chaos.
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Infection

Sungkyunkwan University and UNIST describe new antivirulence agents

Sep. 12, 2025
Researchers from Sungkyunkwan University and the Ulsan National Institute of Science and Technology (UNIST) have patented compounds reported to be useful for the treatment of Staphylococcus aureus infections.
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Infection

The Ohio State University presents new heteroaryl topoisomerase inhibitors

Sep. 10, 2025
The Ohio State University has synthesized DNA topoisomerase II (bacterial) inhibitors reported to be useful for the treatment of bacterial infections.
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DNA and cancer cells
Infection

Gene therapy kills KSHV-infected cells and halts tumor growth

Sep. 10, 2025
No Comments
Researchers from the University of California, Davis have designed a novel gene therapy vector that selectively targets and kills cells infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).
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