Tankyrases (TNKS) are involved in relevant cellular functions such as telomere maintenance or Wnt signaling, and their inhibition may be a potential treatment strategy for the management of hyperproliferative disorders because it counteracts profibrotic changes and blocks the synthesis of extracellular matrix proteins.
Nanjing Mingde New Drug Research Co. Ltd. has divulged pyrimidinone derivatives acting as P2X purinoceptor 3 (P2RX3; P2X3) antagonists reported to be useful for the treatment of cough.
In obstructive sleep apnea (OSA), the collapse of the upper airway at sleep onset leads to a decrease in blood oxygen levels, frequent arousals from sleep and consequently fatigue and daytime sleepiness.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is characterized by an abnormal inflammatory reaction of the lungs to inhaled particles, such as cigarette smoke. On the other hand, the transcription factor interferon responsive factors (IRFs) are key elements in the production of type I and III interferons. A group of researchers in Italy looked into the relationship between interferon regulatory factor 3 (IRF3) and COPD outcomes.
Glucocorticoids are the standard treatment to treat inflammation in asthma, however, they are often associated with cardiovascular disease, osteoporosis or immune suppression risk with chronic use. Novel strategies to combine with traditional treatments, such as those intended to restore hydrogen sulfide (H2S) levels, have emerged as options for treating severe uncontrolled asthma with frequent exacerbations.
Addex Therapeutics Ltd. and Indivior plc have announced the selection of clinical candidates from their γ-aminobutyric acid subtype B (GABA-B) positive allosteric modulator (PAM) research collaboration.
Immorna Biotherapeutics Inc. has received a grant from the Bill & Melinda Gates Foundation to support the clinical development of JCXH-108, a monovalent respiratory syncytial virus (RSV) vaccine based on Immorna’s proprietary mRNA and ready-to-use (RTU)-lipid nanoparticle (LNP) technologies.
Human rhinoviruses (hRVs) are associated with upper respiratory tract infections such as the common cold, otitis media or sinusitis. In immunocompromised individuals or older people, hRVs can exacerbate existing pulmonary conditions such as asthma or chronic obstructive pulmonary disease.
Reistone Biopharma Co. Ltd. has described phosphodiesterase PDE4B1 inhibitors reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, atopic dermatitis, overactive bladder, psoriasis, ulcerative colitis and urticaria, among others.
Beijing Primegene Therapeutics Co. Ltd. has identified azacycloalkane compounds acting as rho kinase 1 (ROCK1; p160-ROCK) and/or rho-associated protein kinase 2 (ROCK 2) inhibitors reported to be useful for the treatment of asthma, cancer, insulin resistance, neurodegeneration, osteoporosis and renal failure.
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