The compound, which showed oral bioavailability of 42.7%, performed similarly well as the licensed drug loratidine in a mouse model of the inflammatory disease allergic rhinitis.

Nagoya University Graduate School of Medicine (Japan) and collaborating institutions aimed to characterize the heterogeneity of myofibroblastic cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma using the KPC mouse model.

In earlier work, researchers from the Institute of Medicinal Biotechnology (Beijing, China) and collaborators identified a small-molecule inhibitor (IMB-H4) of the BamA-BamD interaction. By binding to the intracellular domain of unfolded BamA, IMB-H4 disrupts the BamA-BamD assembly, leading to outer membrane damage and filamentation in gram-negative bacteria.

Using machine learning as an innovative tool for analyzing complex biological systems, researchers integrated bioinformatics with adaptive algorithms and identified dynein light chain LC8-type 2 (DYNLL2) as a key modulator of sepsis progression. Mechanistically speaking, DYNLL2 interacts with p21-activated kinase 1 (PAK1) to regulate bacterial outer membrane vesicle (OMV) internalization and caspase-11 activation.

Researchers from Shanghai Institute of Nutrition and Health and Guangming Advanced Research Institute (China) proposed a new strategy based on a circular RNA (circRNA) encoding human relaxin-2 (cRLN2). circRNAs, thanks to their high stability and low immunogenicity, have been proposed as promising new drugs for several applications.

D3 Bio Inc. has obtained IND clearance from the FDA for D3S‑003, enabling initiation of a first‑in‑human phase I trial in patients with advanced solid tumors harboring KRAS G12D mutations.