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Neurology/psychiatric

CN-045 stimulates remyelination in multiple sclerosis models

Sep. 26, 2024
The differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes (OLs) promotes the remyelination in human brain. In multiple sclerosis (MS), dysfunctional OPC differentiation leads to remyelination failure and subsequent severe neurological disability.
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Pediatric brain illustration
Cancer

ZIC4 overexpression pediatric choroid plexus carcinoma cells

Sep. 26, 2024
Zic family member 4 (ZIC4) is a tumor suppressive transcription factor that is epigenetically silenced in many types of cancers. In the current study, researchers from Children's Cancer Hospital Egypt (CCHE) and affiliated organizations investigated the epigenetic regulation function of ZIC4 in pediatric choroid plexus tumors (CPTs).
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Demyelination of a neuron
Neurology/psychiatric

PF-4778574 exerts neuroprotective effect in EAE models

Sep. 26, 2024
High extracellular glutamate levels damage axons, myelin and oligodendrocytes in the context of inflammatory demyelinating disorders such as multiple sclerosis (MS).
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Neurology/psychiatric

Poltreg studies CAR-Treg cells in neuroinflammatory mouse model

Sep. 26, 2024
Poltreg SA has initiated a preclinical study with CAR-Treg cells in a humanized mouse model of neuroinflammatory disease.
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Ocular

EGR2 protects the eye from uveitis by impacting GDF15 signaling

Sep. 26, 2024
Uveitis is a disease involving the eye, affecting the iris, ciliary body, retina and their associated blood vessels, among others. The non-infectious type of uveitis is linked to immune-related factors and its pathogenesis remains poorly understood.
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Liver tumor treatment conceptual illustration
Biomarkers

RAC1 has prognostic value in hepatocellular carcinoma

Sep. 26, 2024
Hepatocellular carcinoma (HCC) has a poor prognosis due to late diagnosis and lack of effective therapies.
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Neurology/psychiatric

κ-Opioid receptor agonist shows promise for multiple sclerosis

Sep. 26, 2024
To date, therapies for multiple sclerosis (MS) focus on modifying or suppressing the immune system rather than on remyelination. Recent findings have pointed to the κ-opioid receptor (KOR) as a therapeutic target for remyelination, but several KOR agonists have undesired side effects that limit their use. Researchers from the Victoria University of Wellington have tested KOR agonists derived from U-50488 in the preclinical setting for the management of MS.
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Purple-tinted test tubes and dropper
Immune

FDA awards orphan status to Eydisbio’s TAK1 inhibitor

Sep. 26, 2024
The FDA has awarded U.S. orphan drug designation to Eydisbio Inc.’s EYD-001 (formerly HS-276), a highly selective and potent, orally bioavailable TAK1 inhibitor for the treatment of systemic sclerosis. Eydisbio plans to initiate clinical trials in the near future.
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Vaccine vial and syringe
Infection

mRNA-1769 provides better protection against lethal mpox

Sep. 26, 2024
Researchers from Moderna Inc. and affiliated organizations presented preclinical data for the novel mRNA-lipid nanoparticle (LNP) vaccine, mRNA-1769, against mpox virus.
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Holiday notice

Sep. 25, 2024
In accordance with the publishing schedule, BioWorld Science was not published on Tuesday, Sept. 24, 2024.
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