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Endocrine/metabolic

The University of Florida describes new PPARγ agonists

Aug. 5, 2024
The University of Florida has prepared and tested PPARγ agonists reported to be useful for the treatment of diabetes, hyperparathyroidism, metabolic syndrome, multiple myeloma, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), obesity, osteoporosis and Paget disease, among others.
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Cancer

IFM Due identifies mutant-selective EGFR inhibitors

Aug. 5, 2024
IFM Due Inc. has disclosed EGFR (HER1; erbB1) mutant inhibitors reported to be useful for the treatment of cancer.
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Cancer

Angel Pharmaceuticals presents new PARP-7 inhibitors

Aug. 5, 2024
Angel Pharmaceuticals Co. Ltd. has described protein mono-ADP-ribosyltransferase TIPARP (PARP-7; ARTD14) inhibitors reported to be useful for the treatment of cancer.
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Test tubes, dropper
Cancer

Preclinical analysis to optimize dosing regimens for ATM inhibitor WSD-0628

Aug. 5, 2024
Researchers from Wayshine Biopharm Holding Ltd. published new data regarding the preclinical systemic pharmacokinetics (PK), dose proportionality, and central nervous system (CNS) distribution of the novel ataxia telangiectasia mutated (ATM) inhibitor WSD-0628, being developed for the treatment of brain tumors.
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Dollar sign inside vial, syringe
Infection

Anivive receives grant funding for antifungal vaccine

Aug. 5, 2024
Anivive Lifesciences Inc., a One Health technology company, reported the NIH’S National Institute of Allergy and Infectious Diseases (NIAID) has awarded grant funding worth up to $33 million to the company to support the development of a vaccine against the fungus Coccidioides, which causes Valley Fever.
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Antibodies attacking cancer cell
Cancer

Salubris gets EMA clearance for basket trial

Aug. 5, 2024
Salubris Biotherapeutics Inc. has received clearance by the European Medicines Agency (EMA) to begin a first-in-human basket trial of JK-06.
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Illustration of diseased kidney
Nephrology

Latent TGF-β1 complex inhibitor avoids renal fibrosis

Aug. 5, 2024
An antibody that binds to the latent form of transforming growth factor-β1 (TGF-β1) prevented its release into the extracellular matrix and reduced the progression of fibrosis in the kidney. TGF-β is synthesized and secreted into the extracellular matrix in a latent inactive form associated with the latency peptide.
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Illustration of tumor in the liver
Cancer

Dual-target inhibitor shows activity and safety in models of liver cancer

Aug. 5, 2024
Researchers from Changzhi Medical College and affiliated organizations presented the discovery of DYC-1, a novel dual-target inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) and histone deacetylase 8 (HDAC8), being developed for the treatment of hepatocellular carcinoma (HCC).
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Streptococcus pyogenes before and after treatment
Infection

PS-757 fights flesh-eating bacteria, biofilm

Aug. 5, 2024
Investigators at Washington University in St. Louis and Umea University have reported that the small molecule PS-757 was effective in culture and animal models against Streptococcus pyogenes, a gram-positive pathogen responsible for more than 500,000 deaths per year globally.
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Hematologic

WIZ glue degrader restores fetal hemoglobin

Aug. 5, 2024
Scientists at the Novartis Institutes for Biomedical Research (NIBR) in Cambridge have discovered a small molecule that could be used as a therapy for sickle cell disease (SCD). The molecular glue oral degraders of the WIZ transcription factor called dWIZ-1 and dWIZ-2, bind to cereblon (CRBN) and WIZ, marking it for degradation and inducing the expression of fetal hemoglobin (HbF).
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