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Cardiovascular

Opna Bio discovers new YAP1/TEAD interaction inhibitors

Aug. 21, 2024
Opna Bio AG has described transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of arrhythmogenic right ventricular cardiomyopathy, cancer, Holt-Oram syndrome, neurofibromatosis type 2, polycystic kidney disease and Alzheimer’s disease.
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Cancer

New Raf kinase inhibitors disclosed in Enliven Therapeutics patent

Aug. 21, 2024
Enliven Therapeutics Inc. has divulged Raf kinase inhibitors reported to be useful for the treatment of cancer. An exemplified compound (Ex 5 [isomer B] pg 130) inhibited ERK phosphorylation in human melanoma A-375 cells (IC50=12.4 nM) in ELISA assays.
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Infection

UK researchers describe new KARS inhibitors for parasitic infections

Aug. 21, 2024
Researchers at De Montfort University and Loughborough University have identified trifluoroquinazolines acting as lysyl tRNA synthetase (KARS) inhibitors reported to be useful for the treatment of parasitic infections.
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Neurology/psychiatric

Takeda Pharmaceutical divulges new NLRP3 inflammasome inhibitors

Aug. 21, 2024
Takeda Pharmaceutical Co. Ltd. has synthesized NLRP3 inflammasome inhibitors reported to be useful for the treatment of neonatal-onset multisystem inflammatory disease (NOMID/CINCA), Muckle-Wells syndrome, familial cold autoinflammatory syndrome, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disease.
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Infection

Rockefeller University patents new PL-PRO inhibitors for SARS-CoV-2

Aug. 21, 2024
Rockefeller University has disclosed non-structural protein 3 (nsp3; PL-PRO) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Colon cancer illustration
Cancer

Baicalein found to sensitize colorectal cancer cells to radiotherapy

Aug. 21, 2024
Resistance to radiotherapy is a crucial factor in the outcome of colorectal cancer (CRC). The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a key role in cell growth, differentiation, proliferation and immune function.
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Photomicrograph of core biopsy of prostate gland showing histology of adenocarcinoma in patient with elevated PSA.
Cancer

Halda’s RIPTAC therapeutics offer novel mechanism to treat prostate cancer

Aug. 21, 2024
In a presentation at the American Chemical Society meeting, Halda Therapeutics Inc. described its androgen receptor (AR)-targeting RIPTAC (regulated induced proximity targeting chimera) therapeutics as a new class of heterofunctional small molecules designed to selectively kill cancer cells that express tumor-specific targeting protein (TIP) into a stable intracellular ternary complex with a protein essential for cell survival for the treatment of prostate cancer.
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Illustration of intestines with inflammation
Gastrointestinal

Novel NLRP3 degrader ameliorates inflammatory symptoms in colitis models

Aug. 21, 2024
The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein complex that may be activated by exogenous or endogenous signals and is involved in the pathogenesis of several inflammatory disorders.
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Concept art for targeting cancer
Cancer

DDX10 deletion promotes CRC cell apoptosis through ATG10-driven autophagy

Aug. 21, 2024
Colorectal cancer (CRC) is rated as the second most deadly cancer after lung cancer. Identifying new mechanisms responsible for CRC pathogenesis is crucial for the development of new therapies.
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Microscope with beakers and flasks
Endocrine/metabolic

IGC Pharma identifies IGC-1A as potential GLP-1 agonist

Aug. 21, 2024
IGC Pharma Inc. has used its artificial intelligence (AI) modeling to identify the company’s proprietary molecule, IGC-1A, as a potential GLP-1 agonist. The company’s AI model compared IGC-1A and IGC-1C to established drugs such as Ozempic (semaglutide), tirzepatide, retatrutide and metformin, among others, and indicated that they could become effective options for metabolic disorders.
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