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BioWorld - Monday, May 18, 2026
Breaking News: Bundibugyo is harsh reminder of need for broad vaccine strategiesBreaking News: Bundibugyo is harsh reminder of need for broad vaccine strategiesBreaking News: Bundibugyo is harsh reminder of need for broad vaccine strategies
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Cancer

Wigen Biomedicine Technology divulges new PARP inhibitors

Aug. 23, 2023
Wigen Biomedicine Technology (Shanghai) Co. Ltd. has synthesized compounds acting as poly(ADP-ribose) polymerase (PARP; ARTD) inhibitors, preferably PARP-1, reported to be useful for the treatment of cancer.
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Neurology/Psychiatric

Chengdu Kanghong Pharmaceutical patents new Nav1.8 blockers

Aug. 23, 2023
Chengdu Kanghong Pharmaceutical Co. Ltd. has disclosed sodium channel protein type 10 subunit alpha (Nav1.8) channel blockers reported to be...
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CAR T cells attacking cancer cell
Immuno-oncology

Verismo licenses anti-CD19 binders to support Synkir-310 KIR-CAR T-cell therapeutic

Aug. 23, 2023
Verismo Therapeutics Inc. has entered into a licensing agreement with the University of Pennsylvania for worldwide exclusive rights for two newly discovered anti-CD19 binders, the result of a sponsored research agreement between the two parties.
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Cancer

Preclinical characterization of novel TS inhibitor DG-1 presented

Aug. 23, 2023
Thymidylate synthase (TS) is an enzyme essential for DNA synthesis and cell proliferation and is a potential oncoprotein itself. Consequently, TS is considered a molecular target for malignant tumors.
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HIV drugs
HIV/AIDS

NIAID grant supports development of ultra-long-acting HIV integrase inhibitor XVIR-110

Aug. 23, 2023
Exavir Therapeutics Inc. has received a US$3 million award from the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health, to support the development of XVIR-110.
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Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.
Neurology/Psychiatric

Akava announces IND clearance for AKV-9 to enter clinic for ALS

Aug. 23, 2023
Akava Therapeutics Inc. has announced FDA clearance of its IND application for AKV-9 (formerly NU-9) for the treatment of amyotrophic lateral sclerosis (ALS). The company is planning a first-in-human phase I study in healthy subjects.
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Immuno-oncology

Vincerx's antibody-drug conjugate VIP-943 receives FDA clearance for phase I study in AML

Aug. 23, 2023
Vincerx Pharma Inc. has received IND clearance from the FDA to initiate a phase I trial for VIP-943, an antibody-drug conjugate (ADC) for acute...
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Gastrointestinal

Thiophene derivatives acting as Cisd2 activators may prevent NAFLD development and progression

Aug. 23, 2023
The CDGSH iron sulfur domain 2 (Cisd2) is a zinc finger protein that regulates endoplasmic reticulum Ca2+ uptake, maintains intracellular...
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Brain and encephalography
Neurology/Psychiatric

NS-041, a novel KCNQ2/3 activator for the treatment of epilepsy, presented at ACS meeting

Aug. 23, 2023
Voltage-gated potassium channels (KCNQ) control neural excitability and their dysfunction leads to neuronal channelopathies frequently related to...
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Scanning electron micrograph of Lassa virus budding off a cell.
Infection

huMAb combination broadly protects primates against most LASV strains after viral exposure

Aug. 23, 2023
Most of the West African population is at risk of infection with Lassa virus (LASV), which leads to Lassa fever that causes thousands of deaths every...
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