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Home » Topics » Infection » HIV/AIDS

HIV/AIDS
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HIV virus cells

CROI 2024: New options, and concerns, on HIV drug resistance

March 12, 2024
By Mar de Miguel
One topic at the 31st Conference on Retroviruses and Opportunistic Infections (CROI 2024) held in Denver this month was that resistance to antiretroviral therapy (ART) has become a public health problem for people living with HIV. Without a vaccine or a cure, these patients depend on treatments that suppress viremia by preventing the virus from replicating. They are lifelong treatments and, until new advances succeed in eradicating the virus from reservoirs, the only option available.
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HIV/AIDS

The ‘data desert’ of pediatric HIV

March 11, 2024
By Mar de Miguel
Several presentations at the 31st Conference on Retroviruses and Opportunistic Infections (CROI 2024) held in Denver from March 3 to 6, 2024, focused on childhood HIV and highlighted the lack of pediatric data. The epicenter of this pandemic in the youngest is in the southern region of the African continent. However, there are few studies for children with HIV, mostly for the northern hemisphere.
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Illustration of HIV particles
HIV/AIDS

At CROI 2024, challenges and roads to new HIV vaccines

March 7, 2024
By Mar de Miguel
Overall, the story of HIV is one of astounding success. But to declare victory, it will be necessary to develop a vaccine. The opening session of the 31st Conference on Retroviruses and Opportunistic Infections (CROI) 2024 looked back to the failures but also the advances in research, all the steps that over the years brought the basic science knowledge that could bring an HIV vaccine in the future. This year, the former director of the Viral Pathogenesis Laboratory at the NIAID Vaccine Research Center, Barney Graham, was named for the Bernard Field Lecture, where he presented “Modern vaccinology: a legacy of HIV research.”
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Virus particles attacking neuron
HIV/AIDS

CROI 2024: HIV is active in the CNS despite ART

March 5, 2024
By Mar de Miguel
On March 4, 2024, several groups of scientists discussed the challenges of investigating the effects of HIV in the central nervous system (CNS) at the oral abstract session on neuropathogenesis of HIV held during the 31st Conference on Retroviruses and Opportunistic Infections (CROI), in Denver. A cure for HIV will require eliminating the virus in all its reservoirs, those tissues where HIV remains latent but retains the capacity for reactivation and replication. However, despite antiretroviral therapy (ART), the virus could continue to replicate continuously at a low level in some reservoirs, including the CNS.
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Virus particles attacking neuron
HIV/AIDS

CROI 2024: HIV is active in the CNS despite ART

March 5, 2024
By Mar de Miguel
On March 4, 2024, several groups of scientists discussed the challenges of investigating the effects of HIV in the central nervous system (CNS) at the oral abstract session on neuropathogenesis of HIV held during the 31st Conference on Retroviruses and Opportunistic Infections (CROI), in Denver. A cure for HIV will require eliminating the virus in all its reservoirs, those tissues where HIV remains latent but retains the capacity for reactivation and replication. However, despite antiretroviral therapy (ART), the virus could continue to replicate continuously at a low level in some reservoirs, including the CNS.
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HIV/AIDS

Gilead Sciences patents new compounds to treat HIV infection

Jan. 23, 2024
Gilead Sciences Inc. has disclosed compounds reported to be useful for the treatment of HIV infection.
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Pharmaceutical manufacturing
HIV/AIDS

Reithera, Ragon Institute and IAVI collaborate on HIV vaccine

Jan. 23, 2024
Reithera Srl, The Ragon Institute of Mass General, MIT and Harvard, and IAVI have established a collaboration to develop a novel HIV vaccine candidate based on gorilla adenoviral vector (GRAd), with funding by the Bill & Melinda Gates Foundation.
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HIV/AIDS

North American researchers describe new compounds for HIV-1 infection

Dec. 21, 2023
Researchers at Centre Hospitalier de Université de Montréal and University of Pennsylvania have identified compounds reported to be useful for the treatment of HIV-1 infection.
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Transmission electron micrograph of HIV particles
HIV/AIDS

Gates Foundation grant supports Gingko Bioworks’ development of live cell therapeutics for HIV and malaria

Dec. 14, 2023
Ginkgo Bioworks Inc. has received a grant from the Bill & Melinda Gates Foundation to develop a novel cell-based technology for improving protein therapeutics delivery for patients in low- and middle-income countries.
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Cross section illustration of HIV virus parts
HIV/AIDS

Arenaviral therapeutic vaccine HB-500 gets IND clearance for HIV

Nov. 21, 2023
Hookipa Pharma Inc. has received clearance from the FDA for its IND application for HB-500, a novel arenaviral therapeutic vaccine for the treatment of HIV.
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