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Home » Topics » Biomarkers, BioWorld Science

Biomarkers, BioWorld Science
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Cancer

LINC01605 is biomarker, target in pancreatic ductal adenocarcinoma

July 31, 2024
Researchers from Shanghai Jiao Tong University presented data from a study that aimed to assess the role of long intergenic non-protein coding RNA 1605 (LINC01605) in the progression of pancreatic ductal adenocarcinoma (PDAC).
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3D Rendering of tumor microenvironment
Biomarkers

TNFSF9 predicts efficacy of combination therapy in metastatic kidney cancer

July 30, 2024
Researchers from University of Tsukuba published data from a study designed to identify novel biomarkers for predicting treatment responses to nivolumab plus ipilimumab combination therapy.
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Conceptual image for brain cancer treatment
Biomarkers

FERMT1 reduces stemness, shows promise as glioma biomarker

July 29, 2024
Fermitin family homolog 1 (FERMT1), a member of the kindlin family of focal adhesion proteins, plays a pivotal role in mediating integrin-dependent cell adhesion and signaling. Scientists at Fujian Medical University (FJMU) assessed the functional significance of FERMT1 in glioma progression and stemness. 
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Illustration of women's reproductive organs
Biomarkers

ZNF334 as diagnostic biomarker and therapeutic target in cervical cancer

July 23, 2024
Researchers from Chongqing Medical University and affiliated organizations reported findings from studies they performed to assess the role of zinc-finger protein 334 (ZNF334) in cervical cancer.
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Fruit fly muscles showing how well mitochondria produce energy
Infection

Infection and brain neuroinflammation weaken muscles

July 19, 2024
By Mar de Miguel
Muscle fatigue associated with brain inflammation could be prevented by modulating certain cytokines. Researchers at Washington University in St. Louis (WUSTL) have studied inflammation in the CNS in infection models of Escherichia coli, SARS-CoV-2 and amyloid-β toxicity, unveiling its impact on motor function, the role of IL-6 in this process and how to mitigate it in chronic disease.
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Cancer

Inhibiting epigenetic regulator blocks liver cancer development

July 18, 2024
Transposable elements (TEs) are DNA sequences involved in the epigenetic regulation of tumors. KDM1A is an epigenetic regulator overexpressed in liver cancer that suppresses the methylation of histone H3 Lys4 (H3K4) in liver-TEs and as a result, HNF4A expression is silenced and hepatocellular carcinoma (HCC) growth is promoted.
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Biomarkers

AJAP1 de novo variants tied to epilepsy pathogenesis, study finds

July 17, 2024
Adherens junction-associated protein 1 (AJAP1) is a transmembrane protein that inhibits tumor cell migration and is a susceptibility gene for migraine. Recent hypotheses have pointed toward the potential involvement of AJAP1 in epilepsy and other neurological disorders.
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Illustration of human eye
Biomarkers

HBS1L deficiency linked to retinal degeneration

July 16, 2024
Researchers from the University of Miami and Harvard Medical School have published data from a study that assessed the role of recessive variants in the HBS1L gene, which encodes for HBS1-like translational GTPase crucial for ribosomal rescue, in inherited retinal disease.
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Fallopian tubes, ovaries and uterus
Biomarkers

TINAGL1 expression in follicular fluid as a biomarker of diminished ovarian reserve

July 15, 2024
A team at Massachusetts General Hospital conducted research to evaluate the expression levels of the extracellular matrix protein tubulointerstitial nephritis antigen-like 1 (TINAGL1) in the human ovary.
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Biomarkers

ALG3 behind pathogenesis of preeclampsia, study unveils

July 10, 2024
Researchers have hypothesized that asparagine-linked glycosylation protein 3 homolog (ALG3) may be involved in the pathogenesis of preeclampsia by impacting the function of trophoblasts. Preeclampsia is still the leading cause of maternal and perinatal mortality and morbidity, but the mechanism behind it is still not clear.
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