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Home » Topics » Science » Biomarkers

Biomarkers
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Sore throat illustration
Cancer

Study identifies C16orf74 as prognostic biomarker in head and neck cancer

May 27, 2025
No Comments
Head and neck squamous cell carcinoma (HNSCC), which makes up the majority of head and neck cancers, is an aggressive disease with a poor prognosis despite current multimodal treatments. Its progression is strongly linked to immune evasion and impaired immune signaling, highlighting the urgent need for new diagnostic and prognostic biomarkers to improve patient outcomes.
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Lungs and bronchiole
Biomarkers

NEIL2 downregulation worsens COPD symptoms, study finds

May 26, 2025
No Comments
Researchers from the U.S. have published findings regarding the link between low NEIL2 expression and airway inflammation and increased DNA damage.
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Conceptual image for brain cancer treatment
Biomarkers

miR-1290 predicts seizure susceptibility in glioblastoma patients

May 21, 2025
No Comments
Glioblastoma (GBM) is an aggressive cancer from the CNS usually characterized by a very bad prognosis. It is known that around 30%-35% of patients with GBM develop epilepsy as a comorbidity of the disease.
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Immuno-oncology

Targeting B4GALT5 to boost tumor antigen display in pancreatic ductal adenocarcinoma

May 19, 2025
No Comments
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of cases of pancreatic cancer, and prognosis for PDAC remains poor despite treatment advances. One reason is that PDAC downregulates the display of antigens on the surface of tumor cells, helping it evade the patient’s immune system and therapies involving immune checkpoint inhibitors.
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Photomicrograph of hepatocellular carcinoma
Cancer

RGS14: An endogenous inhibitor of G protein-coupled receptors that promotes hepatocellular carcinoma

May 16, 2025
No Comments
Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of primary liver cancer, is typically diagnosed in an advanced stage, meaning a poor prognosis. Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease.
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Biomarkers

GPR171 is a prognostic marker in cervical cancer

May 14, 2025
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Recent evidence has shown that G protein-coupled receptor 171 (GPR171) may be a key T-cell checkpoint in tumor immunity.
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Cancer

PSMD14: a protector protein that jeopardizes bladder cancer patients

May 13, 2025
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Some deubiquitinating enzymes may help protect against cancer, but others appear to promote it. Researchers from the First Affiliated Hospital of Zhejiang University have discovered that the deubiquitinator PSMD14 helps drive bladder cancer, and they have defined at least one signaling pathway through which it works, opening up possibilities for development of new treatments.
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Photomicrograph of fine needle aspiration cytology of a pulmonary nodule showing adenocarcinoma, a type of non-small-cell carcinoma.
Biomarkers

The GTPase GIMAP8 implicated in lung adenocarcinoma

May 12, 2025
No Comments
Researchers at Jilin University and collaborators combed through data in the public Cancer Genome Atlas and identified a potential target for lung adenocarcinoma.
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Close up of woman's bulging eyes
Ocular

Identifying NNMT as a therapeutic target in an autoimmune eye disorder

May 9, 2025
No Comments
Individuals with autoimmune diseases affecting the thyroid can suffer eye complications in the form of Graves’ orbitopathy, in which inflammation in and around the orbit leads to eyelid retraction, eye bulging and other symptoms.
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Photomicrograph of hepatocellular carcinoma
Biomarkers

SLC25A19 predicts prognosis in hepatocellular carcinoma

May 8, 2025
No Comments
Solute carrier family 25 member 19 (SLC25A19) is a transporter protein of thiamine pyrophosphate across cellular membranes, which is needed as a cofactor for multiple metabolic enzymes and is important for homeostasis regulation. It was hypothesized that SLC25A19 may be a pan-cancer marker and a therapeutic target, and more concretely in hepatocellular carcinoma (HCC).
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