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Home » Topics » Science » Biomarkers

Biomarkers
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Colorectal cancer illustration
Cancer

tRF-3021a impairs NK cell function via MICA cleavage, promoting immune escape in colorectal cancer

July 22, 2025
No Comments
Immune evasion continues to limit the effectiveness of cancer immunotherapies. Among emerging regulatory molecules, transfer RNA-derived small RNAs (tsRNAs of 13-48 nucleotides), generated through tRNA cleavage, are gaining attention for their roles in controlling gene expression at both the transcriptional and translational levels. Recent research suggests that abnormal tsRNA expression is closely associated with the development and progression of colorectal cancer.
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Cardiovascular

Bi-allelic variants in POPDC2 cause cardiac conduction defects

July 18, 2025
No Comments
Researchers have identified bi-allelic variants in the POPDC2 gene as the cause of a rare inherited cardiac syndrome characterized by sinus node dysfunction, atrioventricular (AV) conduction defects and hypertrophic cardiomyopathy.
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Biomarkers

Study unveils TNFRSF9 as a marker of abdominal aortic aneurysm

July 17, 2025
No Comments
Abdominal aortic aneurysm is a life-threatening cardiovascular disease characterized by chronic inflammation and irreversible dilatation of the abdominal aorta and is asymptomatic at the early stages of the disease, with diagnosis usually relying on imaging techniques and surgery being the main approach for treating it.
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Kidney illustration
Nephrology

CAF22 serves as a diagnostic marker of hypertensive nephropathy

July 16, 2025
No Comments
Hypertensive nephropathy is a major complication of hypertension characterized by inflammation and fibrosis in the kidneys. Recent findings have suggested that agrin may play a critical role in some tissue types such as in the heart or skeletal muscle.
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Brain and neural networks
Biomarkers

Proteomics finds surprise commonalities as well as differences in neurodegenerative diseases

July 15, 2025
By Nuala Moran
No Comments
The switch will be flicked today to make the world’s largest dementia-related proteomics dataset freely available to researchers, at the same time as members of the consortium which compiled it publish the proteomics signatures of major neurodegenerative diseases that they uncovered in a first trawl of the data.
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DNA illustration
Biomarkers

FASTKD5 genetic variants tied to Leigh syndrome

July 11, 2025
No Comments
FAST kinase domain-containing protein 5 (FASTKD5) is a mitochondrial protein that is needed for processing mRNA in the primary mitochondrial transcript. Several mutations have been found in other proteins involved in mitochondrial metabolism, but mutations in the FASTKD5 gene have not yet been reported.
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Xray showing lung cancer on tablet
Biomarkers

Metabolic markers to predict efficacy of immune checkpoint inhibitors in non-small-cell lung cancer

June 20, 2025
No Comments
Lung cancer is the second most frequent cancer worldwide, and it accounts for 18% of all cancer-related deaths. Most cases of lung cancer involve non-small-cell lung cancer (NSCLC), in which therapy with immune checkpoint inhibitors (ICIs) can improve prognosis, yet up to 75% of patients fail to respond to it. Researchers at the Chinese Academy of Medical Sciences & Peking Union Medical College have identified potential metabolic markers that may help predict which patients are more likely to respond to ICI therapy.
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Cancer tumor in breast illustration
Biomarkers

miR-7974 is a predictor of poor survival in ER+ breast cancer

June 18, 2025
No Comments
Estrogen receptor-positive (ER+) breast cancer remains a major challenge even with well-defined treatment options. The identification of reliable markers for early detection of the disease is crucial for improving patient outcomes.
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Woman and molecular overlay
Aging

Taurine aging biomarker story gets more complicated

June 6, 2025
By Xavier Bofill Bruna
No Comments
A publication based on longitudinal and cross sectional data and led by researchers at the U.S. NIH’s National Institute on Aging published on June 5, 2025, in Science has stated that the impact of taurine supplementation at delaying aging or treating aging-related conditions is context-dependent, and that the circulating levels of taurine are impacted by factors unique to each individual rather than declining with age. To qualify taurine as a true marker of aging, it should change with age across diverse populations over time and ideally supported by longitudinal data.
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Woman and molecular overlay
Aging

Taurine aging biomarker story gets more complicated

June 5, 2025
By Xavier Bofill Bruna
No Comments
A publication based on longitudinal and cross sectional data and led by researchers at the U.S. NIH’s National Institute on Aging published on June 5, 2025 in Science has stated that the impact of taurine supplementation at delaying aging or treating aging-related conditions is context-dependent, and that the circulating levels of taurine are impacted by factors unique to each individual rather than declining with age. To qualify taurine as a true marker of aging, it should change with age across diverse populations over time and ideally supported by longitudinal data.
Read More
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