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Home » Topics » Science » Biomarkers

Biomarkers
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Art concept for medical research
Substance use & poisoning

Ignite Biomedical, Liquid Biosciences discover new biomarkers for substance use disorder

April 9, 2025
Ignite Biomedical Inc. and Liquid Biosciences have announced the discovery of biomarkers to diagnose substance use disorder (SUD). The set of biomarkers includes some that have not previously been associated with addiction and spans all 6 SUDs (opioid, cocaine, methamphetamine, alcohol, nicotine and cannabis use disorders).
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Cancer cells under magnifying glass
Biomarkers

CSPG4 expression discerns EBSCC from conventional ESCC

April 8, 2025
Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare type of esophageal squamous cell cancer (ESCC) characterized by basaloid features and considered to be more aggressive than ESCC. RNA sequencing was performed from 20 pure EBSCC and 11 poorly differentiated ESCC samples; researchers identified chondroitin sulfate proteoglycan 4 (CSPG4) as a potential marker of EBSCC at the mRNA level, which was verified by immunohistochemistry in these same samples.
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Illustration of dividing cancer cells
Biomarkers

L1CAM predicts unfavorable outcome in malignant melanoma

April 7, 2025
Malignant melanoma (MM) is among the most lethal cutaneous neoplasms, frequently tied to metastasis and poor outcomes. Neural cell adhesion molecule L1 (L1CAM) is a protein that has been associated with poor prognosis in several cancer types, but its association with MM is poorly understood.
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Photo of magnifying glass inspecting moles on person's back
Biomarkers

INSM1 is highly sensitive marker in primary and metastatic Merkel cell carcinoma

April 4, 2025
The detection of metastases in Merkel cell carcinoma (MCC) requires additional testing, such as pancytokeratin (panCK) or CK20, with no guarantee of success. Recent findings have identified transcription factor SOX11 and insulinoma-associated protein 1 (INSM1) as sensitive nuclear neuroendocrine markers, but their usefulness in MCC has not been proven.
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Kidneys
Biomarkers

NIPAL4 correlates with poor survival in renal cancer

April 2, 2025
Clear cell renal cell carcinoma (ccRCC) is still a clinical challenge due to its high metastasis rate at diagnosis and therapy resistance. It accounts for about 75%-80% of RCC cases. The magnesium transporter NIPA4 (NIPAL4) may influence tumor progression, but there is lack of knowledge on its prognostic value and role in ccRCC.
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Biomarkers

Rare genetic variants in HECTD2 tied to bipolar disorder

March 28, 2025
A variant burden analysis for bipolar disorder was performed using gene-based aggregation of loss-of-function variants in whole-genome sequencing data from Iceland and the UK Biobank; the association between bipolar disorder and the burden of loss-of-function variants was tested in 13,786 genes.
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Biomarkers

PRTFDC1 expression predicts prognosis, drug response of testicular germ cell tumors

March 26, 2025
Researchers from Guangdong Medical University published data from a study that aimed to identify novel biomarkers that would allow for comprehensive assessment of prognosis and immunotherapy response in patients with testicular germ cell tumors (TGCT).
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Cancer

Increased HKDC1 and phosphorylated RBBP5 emerge as potential targets and prognostic markers in HCC

March 25, 2025
Metabolic reprogramming in cancer involves glycolytic enzymes acquiring noncanonical functions and acting as protein kinases, which contribute to tumor progression and present new therapeutic opportunities. While hexokinase domain-containing protein 1 (HKDC1), a hexokinase family member, has been implicated in tumor growth and immune evasion, its nonmetabolic roles remain poorly understood.
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Biomarkers

DACH1 variant linked to new neurodevelopmental syndrome

March 24, 2025
Branchio-Oto-Renal syndrome 1 (BOR1) is caused by pathogenic variants in the EYA1 gene, and the gene behind the pathogenesis of BOR2 is SIX5. Growing evidence exists regarding GATA and PAX-SIX-EYA-DACH transcriptional networks playing a key role in normal development. A case report of a patient harboring a new variant in the DACH1 gene was recently presented.
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Tau protein in Alzheimer's disease
Biomarkers

Enigma Biomedical selects 4R tau PET imaging biomarkers to advance into clinic

March 21, 2025
Enigma Biomedical USA Inc. has selected two four-repeat tau (4R tau) protein PET imaging biomarkers to advance into phase I studies. These imaging biomarkers show promise as important new tools in advancing understanding of neurodegenerative diseases in which the misfolded 4R tau protein is implicated.
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