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Home » Topics » Science » Biomarkers

Biomarkers
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Biomarkers

New findings tie TLX3 to autism spectrum disorder

Jan. 15, 2025
T-cell leukemia homeobox protein 3 (TLX3) is a key regulator of fate specification of excitatory neurons and found expressed in proliferating granule neuron progenitors (GNPs) of the cerebellum, but its main role is not well known.
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Children in classroom wearing masks
Biomarkers

Rare BTNL8 variants associated with altered intestinal permeability are enriched in MIS-C patients

Dec. 31, 2024
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition following SARS-CoV-2 infection associated with intestinal manifestations. The most common clinical features include fever, abdominal pain, rash, myocardial dysfunction and elevated inflammatory biomarkers.
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Art concept for medical research
Cancer

Circulating splicing factor SRRM1: a potential biomarker and therapeutic target in prostate cancer

Dec. 30, 2024
Prostatic-specific antigen (PSA) is commonly used as a screening tool for prostate cancer but presents limited sensitivity and specificity. Therefore, research efforts are focused on searching for novel noninvasive diagnostic biomarkers.
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COVID-19 research illustration
Biomarkers

miR-1-3p levels predict case severity in hospitalized COVID-19 patients

Dec. 13, 2024

Increasing evidence shows that circulating microRNAs (miRNAs) regulate biological processes involved in COVID-19 complications.


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COVID-19 research illustration
Biomarkers

miR-1-3p levels predict case severity in hospitalized COVID-19 patients

Dec. 10, 2024

Increasing evidence shows that circulating microRNAs (miRNAs) regulate biological processes involved in COVID-19 complications.


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Brain maze
Biomarkers

Biomarker could aid in psychosis diagnosis

Dec. 2, 2024
By Anette Breindl
Researchers at the University of Rochester have described a neuroimaging-based biomarker that could identify individuals with early psychosis, and improved their identification when it was added to a standard neurocognitive diagnostic test. In a group of roughly 160 participants in the Human Connectome Early Psychosis Project, individuals who were in the early stages of psychosis had stronger connections from the thalamus (a midbrain sensory processing area) to the cortex, but weaker connections between different cortical areas, than controls.
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Drug discovery illustration
Biomarkers

Loss-of-function variants linked to neurodevelopmental disorder with hypercholanemia

Nov. 26, 2024
WD repeat domain 83 opposite strand (WDR83OS) encodes the 106-aa (amino acid) protein Asterix, which is a binding partner for CCDC47. More specifically, Asterix heterodimerizes with CCDC47 to form the protein associated with ER translocon (PAT) complex that specifically chaperones large proteins containing transmembrane domains.
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Illustration of gut bacteria on scales being evaluated by AI chip
Gastrointestinal

Machine learning links microbiome composition to bacterial load

Nov. 22, 2024
By Mar de Miguel
Many studies have linked the presence of specific bacteria to various diseases. But a general overgrowth of gut bacteria can be a symptom of different conditions, including colorectal cancer and inflammatory bowel disease.
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DNA mutations or genetic disorder concept art
Biomarkers

HOXB13 gene involved in metastatic omentum carcinoma, study shows

Nov. 21, 2024
Primary tumors arising in the gastrointestinal system, ovary or pancreas may spread and lead to secondary cancers such as metastatic omentum cancer.
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Illustration of gut bacteria on scales being evaluated by AI chip
Gastrointestinal

Machine learning links microbiome composition to bacterial load

Nov. 19, 2024
By Mar de Miguel
Many studies have linked the presence of specific bacteria to various diseases. But a general overgrowth of gut bacteria can be a symptom of different conditions, including colorectal cancer and inflammatory bowel disease. A study counting gut microbiome proposes that microbial load, rather than the disease, could explain the presence of certain pathogens.
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