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BioWorld - Sunday, June 15, 2025
Breaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sector
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HHS to cut staffing levels by 20,000 under efficiency initiative

March 27, 2025
By Mark McCarty
The U.S. Department of Health and Human Services HHS reported a plan to reduce staffing by 10,000 in an immediate reduction, which when paired with retirement initiatives will drop staffing by as many as 20,000.
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Regulatory actions for March 27, 2025

March 27, 2025
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Alvotech, Exelixis, GSK, Intellia, Kashiv, Kelun, Merck, Neurim, Plus, Sanofi, Theratechnologies, Vast.
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Other news to note for March 27, 2025

March 27, 2025
Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Aadi, GV20, Ionis, Kaken, Mitsubishi, Sobi, Turn, Vesigen, Whitehawk.
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In the clinic for March 27, 2025

March 27, 2025
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Aligos, Calidi, IGC, Leap, Merakris , Merakris, Vaximm, Wave Life Sciences.
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Financings for March 27, 2025

March 27, 2025
Biopharmas raising money in public or private financings, including: Epicrispr, Hubble, Jaguar, Tribune.
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Appointments and advancements for March 27, 2025

March 27, 2025
New hires and promotions in the biopharma industry, including: Areteia, Asgard, Atyr, Auregen, Avalo, Biomea Fusion, Photocure, Psyence, Rezolute, Tevogen, Verrica.
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Illustration of green and yellow antibodies, DNA

Bifunction conjunction afoot; multiple players competing

March 27, 2025
By Randy Osborne
Bispecific antibodies have gotten plenty of press in recent years, but less prominent in headlines are bifunctional ones – i.e., those that boast one binding site for an antigen and another site for a non-antibody molecule such as a toxin or drug, taking aim at a single target and bringing a secondary function for extra oomph.
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Come what May: Equillium marches on with itolizumab in GVHD

March 27, 2025
By Randy Osborne
Equillium Inc. is forging ahead with regulatory plans for itolizumab in first-line treatment of patients with acute graft-vs.-host disease (GVHD), despite a phase III disappointment. Shares of the La Jolla, Calif.-based firm (NASDAQ:EQ) closed March 27 at 46 cents, down 29 cents, or 39%, on top-line data from the Equator study testing itolizumab, which is designed to target the CD6-ALCAM signaling pathway.
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BIO survey points to ‘damaging impacts’ of Trump tariffs

March 27, 2025
By Nuala Moran
A survey of members of the Bioindustry Innovation Organization (BIO) has exposed what is at stake for the sector, on both sides of the Atlantic, if proposed tariffs are imposed on pharmaceutical imports to the U.S. "A staggering 94% of biotech firms anticipate surging manufacturing costs if tariffs are placed on imports from the EU,” according to BIO.
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Abstract illustration of pig and human with medical motifs
Drug design, drug delivery & technologies

Ten days of normal survival of a pig liver in a human being

March 26, 2025
By Mar de Miguel
Transplanting an animal organ into a human is now a closer reality following the successful xenotransplantation of a genetically modified pig liver into a patient diagnosed with brain death in China. The operation was intended to evaluate organ function over a 10-day period. This is a complex experimental trial that did not involve removing the patient's liver and still requires further study. However, the positive preclinical results suggest this strategy could save the lives of those waiting for a human organ, at least in certain cases.
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