The overproduction of cytokines by the immune system, often called "cytokine storm" is often present in many life threatening illnesses that are seen in the intensive care unit such as sepsis, burn injury, trauma, lung injury and pancreatitis. Cytokine storm often causes excessive inflammation that can trigger organ failure, the leading cause of death in the ICU. The current standard of care therapies are typically supportive care with little to no active therapies to battle the cytokine storm.