One way psychiatric disorders differ from neurological disorders is by the absence of anatomically defined neuropathology. “Alzheimer's disease, Parkinson's disease or stroke have a very clear picture of what cells are changing and how they're changing. The specific changes are very clear under a microscope, but in psychiatric diseases one hasn't been able to see that,” Daniel Geschwind told BioWorld.

Two research teams independently reported in the Oct. 5, 2022, issues of Nature (Duke University) and Nature Biotechnology (Stanford University) on the development of RNA sensing technologies designed to target cell-specific RNA sequences to form a double-stranded RNA:RNA hybrid that is then edited by endogenous ADAR proteins to remove a stop codon and ultimately enabled to express any protein placed within the construct. The target design typically starts from single-cell RNA transcriptomics data that previously identified cell-specific RNA transcriptomics.

Age-related diseases have been explained as due in part to the excessive generation and accumulation of waste products like the various insoluble protein aggregates observed in nondividing neurons of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and Huntington’s disease.

Investigators at University of British Columbia have reported the precise cellular populations responsible for the inability to regenerate muscle tissues in muscular dystrophy.

New genomic research has increased the understanding of surprising links between diabetic foot ulcers and carcinomas.

Scientists at the University of Connecticut have made progress in understanding the role of the targetable TRPM2 channel in the context of atherosclerosis, as they report in the March 28, 2022, issue of Nature Cardiovascular Research.

In the Feb. 9, 2022, issue of Science Translational Medicine, investigators reported the anatomical location in which the Ebola virus was hiding and persisting in nonhuman primates had otherwise appeared to have been cured by monoclonal therapy prior to the relapse.

Intracranial aneurysms, outwards bulges ballooning out of an artery, are surprisingly common in middle age, with an estimated prevalence of 2% in the general population. While only a small fraction of these common aneurysms actually go on to rupture, one-fourth of these ruptured aneurysms will lead to sudden death before hospitalization.

Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of Nature Cancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could reprogram tumor-promoting M2 macrophages to exert M1 tumor-suppressing activities in animal models of glioblastoma multiforme.

Despite the identification of the APOE gene as the strongest genetic link to late-onset Alzheimer's disease (AD) since 1993 and the subsequent advances in the understanding of AD pathogenesis, the development of effective consensus-directed treatment therapies has yet to be realized.