Induced pluripotent stem cells (iPSCs) had more mutations when they were generated from older donors, and retained an epigenetic signature that was typical of aged cells, but both issues can be addressed.
Though it has become clear that tumor cells are found in the circulation early on in cancer development, metastasis is still thought of as a late event, on the theory that only cells that have accumulated multiple mutations would be capable of establishing outposts.
Brief treatment that combined suppression of the immunoproteasome with CTLA-immunoglobulin was able to prevent graft rejection for an extended period of time – up to half the lifespan of the mice in which the treatment was tested. The findings suggest that it may be possible to develop treatment regimens that reduce or even eliminate the need for constant immunosuppression in transplantees.
Comprehensive profiling of the antibody response to respiratory syncytial virus (RSV) has shown that more than half of the strongest antibodies bound to a site that had not previously been identified as a vaccine target.
Researchers from the National Cancer Institute have published a case report of a woman with KRAS-mutant metastatic colorectal cancer who had a nine-month remission after being treated with an autologous transplant of tumor-infiltrating lymphocytes.
SAN DIEGO – With much of the focus at the Annual Meeting of the American Society of Hematology (ASH) on blood disorders, it can be easy to forget that a large ongoing need is for something that can substitute for blood for short periods of time.
