A broad swath of KRAS-mutated non-small-cell lung cancers (NSCLCs) are sensitive to the effects of blocking nuclear export, offering a possible way to drug KRAS-mutant tumors, researchers reported in the Sept. 29, 2016, issue of Nature.
Double-stranded breaks (DSBs) in DNA can lead to apoptotic cell death if they cannot be repaired satisfactorily, but how cells know when it's time to go remains unclear.
Researchers from the University of California at San Francisco reported that they have engineered T cells to both hone to targets of their choice, and set off gene expression programs of the researchers' choosing.
By combining two materials that are frequently used in surgical procedures, researchers at Northwestern University have created a synthetic "hyperelastic bone" material that could be printed via 3-D printers into shapes that could be further processed "on the fly" in the operating room.
Bioinformatics-based methods to estimate how sensitive non-small-cell lung cancer (NSCLC) would be to different chemotherapy combinations have been reported by scientists from the Greek National Technical University of Athens.
Preclinical work by researchers from Danish Orphazyme ApS has demonstrated that targeting heat-shock protein 70 (Hsp70) could alleviate a number of different lysosomal storage diseases, a group of several dozen rare to ultra-rare disorders united by mutations in proteins that lead to problems with cellular waste disposal.
As evidenced most recently by Allergan plc's purchase of Tobira Therapeutics Inc. and Akarna Therapeutics Ltd., nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are getting a lot of love from the pharma industry these days, with good reason. (See BioWorld Today, Sept. 21, 2016.)
Inhibiting an enzyme that is important for fat synthesis led tumors to shrink in preclinical models of non-small-cell lung cancer, researchers reported in the Sept. 19, 2016, online issue of Nature Medicine.
The behavioral effects of genetic mutations depend strongly on the mouse strain in which they are studied, and in some cases, the same genetic mutation can have opposite effects on behavior, such as increasing anxiety-driven behaviors in some mouse strains and decreasing them in others, researchers have found.
