By taking an in-depth look at the transcription factor network of Mycobacterium tuberculosis, researchers have gained new insights into how the bacterium adapts to environmental changes, including conditions of low oxygen.
Starting with induced pluripotent stem cells (iPSCs), scientists have created the first artificial organ – a functional liver bud, which is the precursor to the mature liver that is normally formed early in embryonic development.
Starting with induced pluripotent stem cells (iPSCs), scientists have created the first artificial organ – a functional liver bud, which is the precursor to the mature liver that is normally formed early in embryonic development.
Genome editing – the ability to change a DNA sequence at a specific site in the genome – could be useful for improving the scientific understanding, and ultimately the treatment, of a multitude of diseases.
Selective serotonin reuptake inhibitors, or SSRIs, increase serotonin signaling in the brain, and they have antidepressant effects, at least in some patients.
Scientifically speaking, big data projects are the order of the day. With increasing technological abilities – in computing power, but also in methods to visualize and map biological phenomena – such projects strive for comprehensiveness, most often indicated by an "ome" attached to their field of study: the genome, the transcriptome, the human microbiome.
By combining Namenda (memantine, Forest Laboratories Inc.) with nitroglycerin, researchers have developed a compound that appears capable of repairing damaged synapses in animal models of Alzheimer's disease.
Polyglutamine stretches in proteins lead to trouble so frequently that there is a whole disease category named after them. The polyglutamine, or polyQ, disorders, of which Huntington's disease is the most famous member, but far from the only one, as "polyglutamine domains have been associated with a lot of pathological conditions," Dartmouth University's Amy Gladfelter told BioWorld Today.
