Scientists have reported evidence that the brain’s equivalent of the lymphatic system, called the “glymph” system, undergoes massive structural changes with the sleep-wake cycle, and that those changes enable it to dispose of toxic waste proteins.
Some therapeutic areas – rare diseases, the more intractable cancers – have a need for more intense drug development efforts because there is nothing that works for them.
A team from South San Francisco based Cytomx Therapeutics Inc. reported today that it has developed an EGFR-targeting “probody” that was activated specifically in the tumor microenvironment, allowing its delivery at higher doses than conventional antibodies to both mice and primates.
Most people tend to think of gene editing as a way to repair faulty genes. But a team from the University of Minnesota has gained new scientific insights into prostate cancer by taking the opposite tack.
The 2013 Nobel Prize in Chemistry was awarded to Martin Karplus, Michael Levitt and Arieh Warshel, “for the development of multiscale models for complex chemical systems.”
The 2013 Nobel Prize in Physiology or Medicine was awarded to James Rothman, Randy Schekman and Thomas Sudhof “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.”
Scientists have developed a method for rapidly profiling the epigenetic state of the entire genome, an advance which opens the door to new insights into which parts of a cell’s DNA are ready to be put to work at any given moment.
The 2013 Nobel Prize in Physiology or Medicine was awarded to James Rothman, Randy Schekman and Thomas Sudhof “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.”
An American-British team has developed a method for assessing how important mutations in specific noncoding regions of the genome are likely to be, and used it to look at nearly 100 cancer genomes to identify likely driver mutations in noncoding locations.
