Acetaminophen (APAP) is a very common nonprescription analgesic, harmless at low doses, that can cause acute liver injury and even death from acute liver failure when overdosed. The temporal course of acetaminophen overdose-induced liver injury (AILI) can be depicted in two stages – injury and recovery.

An international study led by scientists at Duke-NUS Medical School in Singapore has identified signaling for the cytokine IL-11 as representing a potential new therapeutic target for acetaminophen-induced liver injury in mouse models.