About 10% of acute hepatitis cases and 50% of acute liver failure are caused by drug induction, where treatment remains largely limited. The SLIT/ROBO signaling axis is composed of the secretory SLIT proteins (SLIT1, SLIT2 and SLIT3) and their corresponding receptor ROBO. This axis is known to be involved in organ development, angiogenesis and leukocyte migration, as well as cancer metastasis, and has shown protective effects against organ damage.
Pregnane X receptor (PXR) is a transcription factor that plays a crucial role in maintaining bile acid homeostasis by regulating major metabolizing enzymes and transporters.
Hepatic ischemia-reperfusion injury (HIRI) is a common leading cause of liver injury and is associated with several clinical conditions, including liver transplantation, liver resection surgeries and cancer, among others.
Asialoglycoprotein receptor 1 (ASGR1) is a transmembrane protein specifically expressed in hepatocytes that plays a key role in maintaining circulating glycoprotein homeostasis.
Researchers from Inipharm Inc. presented preclinical data for INI-822, a small-molecule inhibitor of HSD17B13, being developed for the treatment of liver disease.
Acetaminophen (APAP) is a very common nonprescription analgesic, harmless at low doses, that can cause acute liver injury and even death from acute liver failure when overdosed. The temporal course of acetaminophen overdose-induced liver injury (AILI) can be depicted in two stages – injury and recovery.
A high-density lipoprotein (HDL) subspecies produced by small intestine, which potently shields the endotoxicity of bacterial lipopolysaccharide (LPS), may protect against gut-derived liver injury, according to a study led by scientists at Washington University School of Medicine (WUSM) in St. Louis.
