Researchers from Nextcure Inc. have reported the development and preclinical characterization of a novel agonist monoclonal antibody (MAb) against V-set and transmembrane domain containing 1 (VSTM-1).
Nextcure Inc. won’t advance the non-small-cell lung cancer (NSCLC) and ovarian cancer cohorts in the stage two portion of its phase I/II study of NC-318, a monoclonal antibody targeting Siglec-15 (S15), as a monotherapy. The data and decision prompted the company stock to shed more than half its value July 13 and several analysts to adjust their price targets downward.
With a 349% increase in stock price since its June debut on U.S. markets, Boston-based Karuna Therapeutics Inc. secures the title of best IPO performer so far in 2019. The stock skyrocketed in November following positive top-line phase II data of Karxt in acute psychosis in patients with schizophrenia, providing a potential read-through to larger indications such as Alzheimer’s disease and pain.
Shares of Nextcure Inc. (NASDAQ:NXTC) have alternately been up sharply lately or down dramatically. Following the weekend release of updated positive clinical data from its NC-318 phase I/II study, the share price nosed down 52.9% Monday.