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Home » Newsletters » BioWorld

BioWorld

July 8, 2011

View Archived Issues

Early Stage Deals Still Wow? Innate Jumps on BMS Alliance

During last week's BIO International Convention in Washington, panelists in a business development session discussed whether biotech firms can count on scoring major dollars by licensing early stage – preclinical or Phase I – programs. Read More

Idera Weathers Big Pharma Partner's Shift in Priorities

Like many biotechs these days, Idera Pharmaceuticals Inc. is feeling the pinch as a big pharma partner shifts its pipeline priorities, leaving the future of Idera's lead TLR9 compound up in the air. Read More

New Study Shows Unexpected Starting Cell for Brain Cancer

Cancer genetics is a notoriously shifting ground. Having developed into a problem through mutations in the first place, cancer cells continue to mutate as the disease progresses. The most obvious problem from a clinical standpoint is that such mutations can render them resistant to therapy – a problem that plagues now-stalwarts like Gleevec (imatinib, Novartis AG) and new stars like Vemurafenib (PLX4032/RG7204, Plexxikon Inc./Roche AG) alike. Read More

NewCo News: TORCell Takes Aim at AML Using Cancer-Killing T Cells

Serious conditions attract serious attention. Acute myeloid leukemia (AML) is a devastating form of cancer with a poor prognosis and limited treatment options. Already, a raft of biotechs has thrown resources at the disease, but with more failure than success. Now, TORCell Therapeutics Inc., a biotech spun out of the Ontario Institute for Cancer Research (OICR) in Toronto, is taking aim at AML with a technology to boost a patient's own double-negative T cells (DNT) – a subpopulation of T lymphocytes that has potent anticancer properties, but comprises only 1 percent of a patient's peripheral blood mononuclear cells. Read More

Saving Cash, Addex Cuts One Fourth of its Work Force

Addex Pharmaceuticals SA is laying off around a quarter of its work force in order to conserve cash and focus its resources on priority projects. The company aims to realize around CHF8 million (US$9.5 million) in annual savings as a result of the measure, which will extend its cash runway by six to nine months, out to the end of 2013. Read More

Stock Movers

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Mesoblast Off-the-Shelf Stem Cells Advance to Phase III

The FDA has cleared Mesoblast Ltd., of Melbourne, Australia, to begin a Phase III trial of its off-the-shelf mesenchymal precursor cells. The goal of the trial will be to reproduce positive results from a pilot trial at the University of Texas MD Anderson Cancer Center. In that study, the product was found to accelerate neutrophil and platelet recovery, with high 100-day patient survival and low rates of graft vs. host disease (GVHD). Read More

Financings Roundup

Clarus Therapeutics Inc., of Northbrook, Ill., withdrew its filing for an initial public offering, stating that the terms currently obtainable in the public marketplace are not sufficiently attractive. The specialty pharma firm had previously hoped to sell 5 million shares for $11 to $13 apiece. Read More

Other News To Note

Inovio Biomedical Corp., of Blue Bell, Pa., expanded its license agreement with the University of Pennsylvania, adding exclusive worldwide licenses for technology and intellectual property for DNA vaccines against pandemic influenza, Chikungunya and foot-and-mouth disease. Read More

Clinic Roundup

Exelixis Inc., of South San Francisco, said that it will report results from its Phase III trial of cabozantinib in medullary cancer (EXAM) by about three months. That provides additional time to reach the prespecified number of progression-free survival events for unblinding. Read More

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