Salix Pharmaceuticals Inc. put another smile on the faces of investors with word from the FDA that subcutaneous Relistor (methylnaltrexone bromide) is approvable in opioid-induced constipation (OIC) for chronic non-cancer pain based on the data submitted in the supplemental new drug application (sNDA). Read More
Roche AG reported Monday that a pivotal trial combining the MEK-inhibitor cobimetinib with Zelboraf (vemurafenib) met its primary endpoint, providing a statistically significant increase in progression-free survival (PFS) compared to Zelboraf alone for patients with previously untreated BRAF-positive metastatic melanoma. Read More
Otonomy Inc. is hoping public investors will prove as enthusiastic as private investors in backing otology-focused drug development, adding its name to the growing biotech initial public offering (IPO) queue, seeking as much as $86.3 million and a listing on Nasdaq under the ticker OTIC. Read More
HONG KONG — Researchers here have elucidated a previously unknown signaling pathway involved in mediating the synaptic dysfunctions associated with Alzheimer's disease (AD) and have identified a promising new small-molecule disease-modifying intervention that may delay progress of the disease. Read More
LONDON – It looks like the fifth time is lucky for Abbvie Inc. after Shire plc agreed to open negotiations on a sale following an increased offer of £53.20 (US$90.98) per share, valuing the company at £31 billion. Read More
TOKYO – Despite a protest by a 110-strong group of shareholders that comprises the founding family and former executives of Takeda Pharmaceutical Co. Ltd., Japan's largest drug manufacturer, Christophe Weber has been approved as the company's first foreign president and chief executive officer. Read More
HONG KONG – China has indicted two investigators linked to the bribery scandal that has rocked Glaxosmithkline plc. The couple – 58-year-old British man Peter William Humphrey and his 61-year-old American Chinese wife Yu Yingzeng – was arrested in Shanghai last August. Read More
BioWorld has reported, incrementally, how the regenerative medicine sector has been recognized as pivotal for the development of the next generation of innovative medicines. Read More
Assembly Biosciences Inc., of New York, began trading on Nasdaq Monday under the ticker "ASMB" after going public through a reverse merger of Ventrus Biosciences Inc. and Assembly Pharmaceuticals Inc. that became effective July 11. Read More
Trevi Therapeutics Inc., of New Haven, Conn., said the first patient was enrolled in the pivotal study of Nalbuphine extended release (ER) in hemodialysis patients with uremic pruritus. Read More
Eli Lilly and Co., of Indianapolis, said results from its non-clinical study in genetically engineered mice examining combination therapy with the murine version of the beta-amyloid antibody N3pG and beta-secretase inhibitor BACE (LY2811376) found that combination therapy was more effective in removing clumps of amyloid-beta protein in the brain use of one therapy. Read More
