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Home » Newsletters » BioWorld

BioWorld

April 28, 2025

View Archived Issues
M&A letters over missing puzzle pieces

Shock value: Merck’s $3.9B Springworks grab provides jolt

The biggest M&A activity of the year arrived in the form of Merck KGaA’s earlier-disclosed agreement to buy Springworks Therapeutics Inc. for $47 per share in cash, which represents an equity value of about $3.9 billion and an enterprise value of $3.4 billion, based on Stamford, Conn.-based Springworks’ cash in the bank as of the end of last year. Read More

CG Oncology’s bladder cancer therapy holding its own against J&J drug

Shares of CG Oncology Inc. gained 25% April 28 on the back of phase III data presented at the American Urological Association meeting over the weekend showing its cretostimogene grenadenorepvec yielded durable response rates, as well as an enviable safety profile, in patients with high-risk non-muscle invasive bladder cancer unresponsive to Bacillus Calmette Guerin treatment with carcinoma in situ with or without Ta or T1 disease. Read More
Artistic rendering of the KRAS protein.

AACR 2025: Revolution has early stage KRAS success in NSCLC

Early phase I data for Revolution Medicines Inc.’s RAS(ON) G12D-selective inhibitor zoldonrasib encouraged both the company and the analysts. Initial study data produced a 61% objective response rate in 11 solid tumor patients receiving the 1,200-mg dose once a day. The disease control rate for 16 patients came in at 89%. Read More
Conceptual image for brain cancer treatment

FDA issues CRL for Telix's glioma imaging agent, wants more data

The U.S. FDA issued a complete response letter (CRL) to Telix Pharmaceuticals Ltd. for its NDA for glioma imaging agent, TLX-101-CDx (floretyrosine F18 or 18F-FET, Pixclara), citing the need for additional confirmatory clinical evidence. Read More
Vyvgart Hytrulo

Argenx’s Vyvgart, Camurus’ Oczyesa among 16 recommended by CHMP

Argenx NV is now well on the way to establishing a Vyvgart (efgartigimod alfa) franchise in severe autoimmune diseases, after getting the nod from the EMA in the treatment of progressive or relapsing chronic inflammatory demyelinating polyneuropathy. Read More
IPO-coins.png

China pharma migration: Hengrui greenlighted for Hong Kong IPO

Jiangsu Hengrui Pharmaceuticals Co. Ltd. is the latest mainland China pharmaceutical company to seek a capital raise on the Hong Kong stock exchange, winning clearance April 28 from the China Securities Regulatory Commission to float new H-shares. Read More
Illustration of scary hand overshadowing crouching girl

Psychedelics modulate neuroimmune interactions that control fear

Research of the neuroimmune mechanisms involved in stress-related fear revealed how astrocytes interact with neurons in the amygdala. The study, led by Harvard scientists, also unveiled that this interaction recruited monocytes to the meninges during chronic stress and showed how psychedelic compounds reversed monocyte accumulation in the meninges and reduced fear behavior. Read More
US flag, stock market chart, White House

100 days of uncertainty

The first 100 days of the Trump administration have been nothing short of chaotic, both in the U.S. and throughout the world. Shining a light through the uncertainty, BioWorld continues to cover the administration’s latest policy decisions and actions affecting the life sciences sector, as well as their impacts across the globe. It’s all right here at Trump administration impacts. Read More

New feature: NME Digest

BioWorld is pleased to begin providing a new quarterly dynamic table featuring new molecular entities (NMEs) revealed for the first time in current literature, at congresses and in company communications during the quarter. NMEs include compounds chosen for further pharmacological evaluation or as clinical candidates; new leads whose structural optimization could provide new therapeutic agents; new additions to the structural diversity of known mechanistic classes of drugs; and new pharmacological tools for investigating drug targets. Read More

ICYMI: Week in review, April 21-25, 2025

A quick look back at top stories. Read More

Biggest gainers and losers for April 21-25, 2025

The top 10 biopharma stock gainers and losers for the week. Read More

Appointments and advancements for April 28, 2025

New hires and promotions in the biopharma industry, including: Cptx. Read More

Financings for April 28, 2025

Biopharmas raising money in public or private financings, including: Alcyone, Araceli, Avidicure, Ensysce, Innate, Orphan, Oryzon, Sanofi. Read More

In the clinic for April 28, 2025

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Alx Oncology, Cytoagents, Genentech, Geovax, Neurocrine, Realta, Roche, Vyne. Read More

Other news to note for April 28, 2025

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Astex, Caamtech, Caribou, Criceto, Inventiva, Mosaic, Orion, Otsuka, Transneural. Read More

Regulatory actions for April 28, 2025

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Akeso, Innocare, J&J, Junshi. Read More

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