The Cancer Genome Atlas, a comprehensive program that used sequencing to understand the genomic landscapes of 33 different tumor types, published its results in almost 30 papers in half a dozen different Cell Press journals. Read More
Sigilon Therapeutics Inc., a Cambridge, Mass.-based startup working to encapsulate therapeutic cells for chronic disease inside microspheres invisible to the immune system's normal fibrotic response to foreign implants, has landed a $473 million deal with Eli Lilly & Co. to develop a potential treatment of type 1 diabetes (T1D). Read More
LONDON – Oxford Biodynamics plc claims its epigenetic biomarker technology has cracked the problem of singling out the half of newly diagnosed rheumatoid arthritis (RA) patients who will not respond to methotrexate, potentially ending one of the major challenges in managing the disease and opening the way for patient stratification in clinical trials. Read More
DNA methylation loss, which can lead to increased transcription, is a frequent feature of cancer cells. Now, researchers have published a paper in the April 2, 2018, issue of Nature Genetics that demonstrates that such methylation loss occurs in almost all normal tissues as well, and that it can be used as a "mitotic clock" to estimate how often a cell has replicated. Read More
PERTH, Australia – A Senate inquiry on transvaginal mesh products is calling for patient registries for high-risk implantable devices, tighter postmarketing requirements and mandatory adverse event reporting requirements. Read More
